Evidence map›Paper›PMID 32674323›Full record

ArticleJournal of fungi (Basel, Switzerland)2020

Modeling Approaches Reveal New Regulatory Networks in

Enzo Acerbi, Marcela Hortova-Kohoutkova, Tsokyi Choera, Nancy Keller, Jan Fric, Fabio Stella, Luigina Romani, Teresa Zelante

Open access · goldAbstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Metabolite analysis ofFrontiers in immunology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Enzo AcerbiNlytics Pte. Ltd., Singapore 637551, Singapore.
Marcela Hortova-KohoutkovaCentre for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital Brno, 65691 Brno, Czech Republic.
Tsokyi ChoeraDepartment of Medical Microbiology and Immunology, Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.
Nancy KellerDepartment of Medical Microbiology and Immunology, Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0002-4386-9473
Jan FricCentre for Translational Medicine, International Clinical Research Centre, St. Anne's University Hospital Brno, 65691 Brno, Czech Republic.ORCID 0000-0001-6642-797X
Fabio StellaDepartment of Informatics, Systems and Communication, University of Milano-Bicocca, Viale Sarca 336, Building U14, 20126 Milan, Italy.
Luigina RomaniDepartment of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
Teresa ZelanteDepartment of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
University of Perugia · ITUniversity of Wisconsin–Madison · USInstitute of Haematology and Blood Transfusion · CZUniversity Hospital Brno · CZUniversity of Milano-Bicocca · IT

Funding

European Social Fund and European Regional Development Fund ENOCH CZ.02.1.01/0.0/0.0/16_019/0000868European Social Fund and European Regional Development Fund Project MAGNET CZ.02.1.01/0.0/0.0/15_003/0000492Ministry of Health of the Czech Republic NV18-06-00529The Italian Grant "Programma per Giovani Ricercatori - Rita Levi Montalcini 2013 PGR13XNIDJ
6 · The paper itself

Abstract

Systems biology approaches are extensively used to model and reverse-engineer gene regulatory networks from experimental data. Indoleamine 2,3-dioxygenases (IDOs)-belonging in the heme dioxygenase family-degrade l-tryptophan to kynurenines. These enzymes are also responsible for the de novo synthesis of nicotinamide adenine dinucleotide (NAD+). As such, they are expressed by a variety of species, including fungi. Interestingly,

Indexed as

Aspergillus fumigatusBayesian networkscontinuous time Bayesian networksgene network inferencegene network reconstructionmodelingtryptophan metabolism

Identifiers

PMID32674323
PMCPMC7557846
OpenAlexW3042240383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.