ReviewPathogens (Basel, Switzerland)2020
Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms.
Review in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 6 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Role of nutrition in prevention of dental caries in children and adolescents: a systematic review.BMC oral health · 2026Pooled it
- Unlocking the potential of probiotic administration in caries management: a systematic review.BMC oral health · 2024Pooled it
- A systematic review of Streptococcus Mutans and Veillonellae species interactions in dental caries progression: Positive or Negative impact?F1000Research · 2024Pooled it
- Examining the Role of Vitamin D in Caries Susceptibility in Children's Deciduous Teeth: A Systematic Review.Nutrients · 2023Pooled it
- Peptide Designs for Use in Caries Management: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Pooled it
- Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children: A Pilot Randomized Controlled Trial.Nutrients · 2025Trial
- Smartphone-Based Telemonitoring for Better Oral Health With Toothbrushes: 6-Month Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- The clinical and microbiological efficacy of a zinc-citrate/hydroxyapatite/potassium-citrate containing toothpaste: a double-blind randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- Trial
- Black Cumin Seed Oil Disrupts Structural Biomass and Attenuates Porphyrin-Associated Maturation in Mature Oral Microcosm Biofilms: An In Vitro Study.Biomedicines · 2026Article
- Coumarin-Mediated Inhibition of Diadenylate Cyclase Correlates with Impaired Biofilm Formation inACS infectious diseases · 2026Article
- Application of an MTT-Based Colorimetric Assay to Evaluate SHED Metabolites in Inhibiting Oral Bacteria Growth.European journal of dentistry · 2026Article
- The Role of Microbiota in Type 1 Diabetes: Insights into Dysbiosis and Immune Interactions.Nutrients · 2026Review
- Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases.MicrobiologyOpen · 2026Review
- Enhanced antibacterial activities of zirconia nanoparticles modified with yttrium oxide and alumina.Scientific reports · 2026Article
- In vitro and in silico characterization of Crocatin A from red betel leaves: targeting DNA gyrase B and DNA ligase of Enterococcus faecalis with ADMET-based druglikeness analysis.BMC chemistry · 2026Article
- Classification of the tongue microbiota and its associations with lifestyle factors and health status.NPJ biofilms and microbiomes · 2026Article
- Association between Live Dietary Microbes and Root Caries: A Cross-Sectional Study with a Predictive Risk Model.Oral health & preventive dentistry · 2026Article
- Taguchi optimisation of ZnO and GO-integrated HA nanocomposite with improved antibacterial performance.Scientific reports · 2026Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Dental caries is one of the most common microbe-mediated oral diseases in human beings. At present, the accepted etiology of caries is based on a four-factor theory that includes oral microorganisms, oral environment, host, and time. Excessive exposure to dietary carbohydrates leads to the accumulation of acid-producing and acid-resistant microorganisms in the mouth. Dental caries is driven by dysbiosis of the dental biofilm adherent to the enamel surface. Effective preventive methods include inhibiting the cariogenic microorganisms, treatment with an anti-biofilm agent, and sugar intake control. The goal is to reduce the total amount of biofilm or the levels of specific pathogens. Natural products could be recommended for preventing dental caries, since they may possess fewer side effects in comparison with synthetic antimicrobials. Herein, the mechanisms of oral microbial community development and functional specialization are discussed. We highlight the application of widely explored natural products in the last five years for their ability to inhibit cariogenic microorganisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.