Evidence map›Paper›PMID 32674272›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Substandard Quality of the Antimicrobials Sold in the Street Markets in Haiti.

Théodule Jean-Baptiste, John F Carpenter, Kevin Dahl, Wellington Derameau, Rosemela Veillard, John Redford Jacquet, Pierre Ludens Osselyn, Albert Figueras

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Théodule Jean-BaptisteLABMES, Faculté de Médecine et de Pharmacie, Université d'Etat d'Haïti, Port-au-Prince HT6110, Haiti.ORCID 0000-0003-2040-2691
John F CarpenterDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kevin DahlKBI Biopharma, Boulder, CO 80301, USA.
Wellington DerameauLABMES, Faculté de Médecine et de Pharmacie, Université d'Etat d'Haïti, Port-au-Prince HT6110, Haiti.
Rosemela VeillardGroupe Haitien de Recherche, d'Innovation et de Créativité (GHRIC), Tabarre HT6124, Haiti.
John Redford JacquetLABMES, Faculté de Médecine et de Pharmacie, Université d'Etat d'Haïti, Port-au-Prince HT6110, Haiti.ORCID 0000-0002-4905-5657
Pierre Ludens OsselynLABMES, Faculté de Médecine et de Pharmacie, Université d'Etat d'Haïti, Port-au-Prince HT6110, Haiti.
Albert FiguerasDepartament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, E-08035 Barcelona, Spain.ORCID 0000-0002-2740-2013
University of Haiti · HTUniversitat Autònoma de Barcelona · ESUniversity of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This pilot study was conducted to analyze the quality of the antimicrobials sold in the street markets in Port-au-Prince, Haiti. A total of 258 packs containing antimicrobials were bought in 28 street markets in Port-au-Prince (Haiti). Tablets and contents of capsules included in 196 packs were analyzed using a Raman handheld spectrometer (NanoRAM of BWTEK, Model: BWS456-785) during the first quarter of 2019. Three out of 11 antimicrobials (Amoxicillin, Metronidazole, and Cotrimoxazole) had a high spectral match with an HQI ≥ 90 to the respective authentic medicine for more than 95% of their tablets/capsules. For six antimicrobials (Tetracycline, Erythromycin, Cloxacillin, Azithromycin, Clarithromycin, and the combination Amoxicillin + Clavulanic Acid) none of their tablets/capsules showed a sufficient spectral match with the authentic medicine. This finding indicates that these products sold in the markets did not contain the labeled drug and/or contained a degraded drug. In addition to the fact that prescription antimicrobials can be purchased in street markets, the present field study found that for most of them (including "Watch" antimicrobials according to the AWaRe classification) were substandard, which contributes to the present antimicrobials resistance epidemic.

Indexed as

antimicrobial resistanceAWaRe classificationHaitipharmaceutical qualitystreet marketssubstandard medicines

Identifiers

PMID32674272
PMCPMC7399874
OpenAlexW3043365912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.