ArticleNature2020
SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 155 citations in OpenAlex.
- Review
- The Role of RNA Interactions with PIWI in Regulating Gametogenesis, Fertilization, and Early Development Across Species.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Hijacking pre-tRNA enables LTR-retrotransposon-initiated constitutive heterochromatin formation.Science advances · 2026Article
- Exercise inhibits proliferation and induces apoptosis of lung adenocarcinoma cells via the POU2F2-SPOCD1-PI3K/AKT signaling axis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Transcriptional perturbation of LINE-1 elements reveals their cis-regulatory potential.EMBO reports · 2026Article
- Transposable element regulation in mammalian germ cells and other contexts: multilayered repression, fertility, and regulated activation.Epigenomics · 2026Review
- PIWI-Interacting RNAs in brain health and disease: biogenesis, mechanisms, and therapeutic horizons.Psychopharmacology · 2026Review
- Establishment of DNA methylation during primate germ cell development.Nature communications · 2026Article
- A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation.The EMBO journal · 2026Article
- DAXX governs the silencing of LINE1 during spermatogenesis in mice.Nucleic acids research · 2026Article
- Article
- Epigenome editing based treatment: Progresses and challenges.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- Gonocytes in Transition: Establishing the Male Germline Identity.Advances in experimental medicine and biology · 2026Review
- Small Non-coding RNAs and Male Infertility.Advances in experimental medicine and biology · 2026Review
- SPOCD1 expression in clear cell renal cell carcinoma: its implications for the prognosis and immunotherapy.World journal of surgical oncology · 2025Article
- Epigenetic regulation by DNA methylation, histone modifications and chromatin remodeling complexes in controlling spermatogenesis and their dysfunction with male infertility.Cellular and molecular life sciences : CMLS · 2025Review
- Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease.Nature reviews. Molecular cell biology · 2025Review
- Genetic and transcriptional insights reveal hepatitis C virus as a driver of kidney cancer.Infectious agents and cancer · 2025Article
- DNA methylation at retrotransposons protects the germline by preventing NRF1-mediated activation.EMBO reports · 2025Article
- Genetic regulation of sperm DNA methylation in cattle through meQTL mapping.BMC genomics · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
13 authors at 4 institutions in 3 countries.
Ansgar ZochCentre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2071-1590
Tania Auchynnikava *Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.
Rebecca V Berrens *Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Yuka Kabayama *Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Theresa SchöppCentre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Madeleine HeepCentre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Lina VasiliauskaitėCentre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Yuvia A Pérez-RicoInstitut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Paris, France.ORCID http://orcid.org/0000-0001-8436-0748
Atlanta G CookWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.
Alena ShkumatavaInstitut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Paris, France.ORCID http://orcid.org/0000-0001-9286-4700
Juri RappsilberWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5999-1310
Robin C AllshireWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.
Dónal O'CarrollCentre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK. donal.ocarroll@ed.ac.uk.ORCID http://orcid.org/0000-0002-8626-2217
MRC Centre for Regenerative Medicine · GBWellcome Centre for Cell Biology · GBCentre National de la Recherche Scientifique · FRUniversity of Cambridge · GB
Funding
Medical Research Council MR/K017047/1Wellcome Trust 095021Wellcome Trust 103139Wellcome Trust 106144Wellcome Trust 108504Wellcome Trust 200885Wellcome Trust 200885/Z/16/ZWellcome Trust 200898Wellcome Trust 200898/Z/16/ZWellcome Trust 203149Wellcome Trust 213612
Abstract
In mammals, the acquisition of the germline from the soma provides the germline with an essential challenge: the need to erase and reset genomic methylation
Indexed as
AnimalsArgonaute ProteinsChromatin Assembly and DisassemblyDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3ADNA Transposable ElementsFemaleFertilityGene SilencingGenes, Intracisternal A-ParticleLong Interspersed Nucleotide ElementsMaleMiceRNA, Small InterferingSpermatogenesisArgonaute ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Transposable ElementsDnmt3a protein, mouseDnmt3l protein, mousePIWIL4 protein, mouseRNA, Small Interfering
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.