Evidence map›Paper›PMID 32674034›Full record

ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2020

SARS-CoV-2 viral load assessment in respiratory samples.

Steven Kleiboeker, Scott Cowden, James Grantham, Jamie Nutt, Aaron Tyler, Amy Berg, Michelle Altrich

Abstract read
In one paragraph

Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Steven KleiboekerViracor Eurofins Clinical Diagnostics, Lee's Summit, MO 64086, USA. Electronic address: stevekleiboeker@viracor-eurofins.com.
Scott CowdenViracor Eurofins Clinical Diagnostics, Lee's Summit, MO 64086, USA.
James GranthamViracor Eurofins Clinical Diagnostics, Lee's Summit, MO 64086, USA.
Jamie NuttViracor Eurofins Clinical Diagnostics, Lee's Summit, MO 64086, USA.
Aaron TylerViracor Eurofins Clinical Diagnostics, Lee's Summit, MO 64086, USA.
Amy BergViracor Eurofins Clinical Diagnostics, Lee's Summit, MO 64086, USA.
Michelle AltrichViracor Eurofins Clinical Diagnostics, Lee's Summit, MO 64086, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-time reverse transcriptase polymerase chain reaction (rRTPCR) has been the main method for diagnosis of SARS-CoV-2 infection in the early stages of the COVID-19 pandemic. De-identified results from upper and lower respiratory samples submitted to a reference laboratory demonstrated a positivity rate of 14.9 % (4428 of 29,713 samples tested). Distribution of results by birth year cohort and specimen type suggested general consistency in mean, median and peak values but higher positivity rates in individuals born from 1964 to 1974. Female patients had a significantly lower positivity rate (P < 0.0001), although similar load mean and median values, compared to males. Overall, 15.3 % (676 of 4428 positive results) of positive results had viral loads greater than 8 log10 copies/mL, with occasional samples exceeding 10 log10 copies/mL. These results support quantitative assessment of SARS-CoV-2 viral load in patient testing and efforts to control viral transmission.

Indexed as

Clinical Laboratory TechniquesViral LoadAdultAgedAged, 80 and overAge FactorsBetacoronavirusChildChild, PreschoolCoronavirus InfectionsCOVID-19COVID-19 TestingCOVID-19 VaccinesFemaleHumansInfantCOVID-19 VaccinesRT-PCRSARS-CoV-2Viral load diagnostic

Identifiers

PMID32674034
PMCPMC7235577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.