Evidence map›Paper›PMID 32673591›Full record

Observational studyCell metabolism2020

Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.

Sofia Cienfuegos, Kelsey Gabel, Faiza Kalam, Mark Ezpeleta, Eric Wiseman, Vasiliki Pavlou, Shuhao Lin, Manoela Lima Oliveira, Krista A Varady

3 registry-linked trialsOpen access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 334 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
334citing papers in PubMed, 22 pooled it
36.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03867773 nacompletednot on this map

Time Restricted Feeding (4-hour Versus 6-hour) for Weight Loss in Obese Adults

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2019 to 2019Enrolled82ConditionsObesity, DiabetesArmsTime restricted feeding
NCT05031429 nacompletednot on this mapstarted 2022, after this paper: background citation

Time Limited Eating in New-Onset Type 1 Diabetes: Feasibility, Acceptability, and Effect on β-cell Function

TypeinterventionalSponsorChildren's Hospital Los AngelesRan2022 to 2023Enrolled12ConditionsType 1 DiabetesArmsTime Limited Eating
NCT05124847 nacompletednot on this mapstarted 2021, after this paper: background citation

Time Restricted Eating as a Treatment for Pediatric Obesity

TypeinterventionalSponsorFundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludRan2021 to 2023Enrolled30ConditionsInfant Obesity, Hepatic Steatosis, Metabolic Syndrome, Insulin ResistanceArmsStandard Care, Time restricted eating
3 · Its place in the literature

Who cites it

334 citing papers in PubMed, 22 syntheses or guidelines pooled it, 556 citations in OpenAlex.

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274 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sofia CienfuegosDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Kelsey GabelDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Faiza KalamDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Mark EzpeletaDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Eric WisemanDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Vasiliki PavlouDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Shuhao LinDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Manoela Lima OliveiraDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Krista A VaradyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: varady@uic.edu.
University of Illinois Chicago · US

Funding

Alternate day fasting combined with exercise for the treatment of NAFLDR01DK119783 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VARADY, KRISTA AMY · 2019 to 2022
$1.4M
NIDDK NIH HHS R01 DK119783
6 · The paper itself

Abstract

Time-restricted feeding (TRF) regimens have grown in popularity; however, very few studies have examined their weight-loss efficacy. We conducted the first human trial (Clinicaltrials.gov NCT03867773) to compare the effects of two popular forms of TRF (4 and 6 h) on body weight and cardiometabolic risk factors. Adults with obesity were randomized to 4-h TRF (eating only between 3 and 7 p.m.), 6-h TRF (eating only between 1 and 7 p.m.), or a control group (no meal timing restrictions). After 8 weeks, 4- and 6-h TRF produced comparable reductions in body weight (∼3%), insulin resistance, and oxidative stress, versus controls. Energy intake was reduced by ∼550 kcal/day in both TRF groups, without calorie counting. These findings suggest that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss. These diets may also improve some aspects of cardiometabolic health.

Indexed as

FastingAdolescentAdultAgedBody WeightCardiovascular DiseasesFemaleHumansMiddle AgedObesityRisk FactorsWeight LossYoung Adultblood pressurebody weightenergy intakeinsulin resistanceintermittent fastingmetabolic diseaseobesityplasma lipidstime-restricted feeding

Identifiers

PMID32673591
PMCPMC9407646
OpenAlexW3043503484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.