Evidence map›Paper›PMID 32673587›Full record

ReviewTrends in biotechnology2020

Engineering Heart Morphogenesis.

Christian J Mandrycky, Nisa P Williams, Ivan Batalov, Danny El-Nachef, Bernadette S de Bakker, Jennifer Davis, Deok-Ho Kim, Cole A DeForest, Ying Zheng, Kelly R Stevens and 1 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Engineered platforms for mimicking cardiac development and drug screening.Cellular and molecular life sciences : CMLS · 2024
    Review
  4. Article
  5. Engineering Three-Dimensional Vascularized Cardiac Tissues.Tissue engineering. Part B, Reviews · 2022
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Christian J MandryckyInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Nisa P WilliamsInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Ivan BatalovInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Danny El-NachefInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Pathology, University of Washington, Seattle, WA, USA.
Bernadette S de BakkerClinical Anatomy and Embryology, Department of Medical Biology, AMC, University of Amsterdam, Amsterdam, The Netherlands.
Jennifer DavisInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA; Department of Pathology, University of Washington, Seattle, WA, USA.
Deok-Ho KimInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Medicine/Cardiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Cole A DeForestInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA; Department of Chemical Engineering, University of Washington, Seattle, WA, USA.
Ying ZhengInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA.
Kelly R StevensInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA; Department of Pathology, University of Washington, Seattle, WA, USA.
Nathan J SniadeckiInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA; Department of Mechanical Engineering, University of Washington, Seattle, WA, USA. Electronic address: nsniadec@uw.edu.
University of Washington · USJohns Hopkins University · USUniversity of Amsterdam · NL

Funding

Integrating Transcriptome Reprogramming Into Cardiac Plasticity Regulatory MechanismsR01HL141187 · NHLBI · UNIVERSITY OF WASHINGTON · PI Jennifer Michelle Davis · 2018 to 2026
$4.0M
Uncovering The Mechanogenomic Basis For Cardiac PlasticityR01HL142624 · NHLBI · UNIVERSITY OF WASHINGTON · PI Jennifer Michelle Davis · 2018 to 2026
$3.8M
Perfusable 3D human cardiac constructs for heart regenerationR01HL141570 · NHLBI · UNIVERSITY OF WASHINGTON · PI MURRY, CHARLES E, ZHENG, YING · 2018 to 2021
$3.3M
Thermogenetic activation of engineered tissue for cardiac repairDP2HL137188 · NHLBI · UNIVERSITY OF WASHINGTON · PI STEVENS, KELLY R · 2016 to 2016
$2.6M
DISEASE MODELING AND PHENOTYPIC DRUG SCREENING FOR DYSTROPHIC CARDIOMYOPATHYR01HL146436 · NHLBI · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2019 to 2022
$2.2M
Mechanotransduction by Melusin in Cardiac HypertrophyR01HL149734 · NHLBI · UNIVERSITY OF WASHINGTON · PI SNIADECKI, NATHAN JOHN · 2020 to 2023
$2.1M
A NANOPATTERNED MEA-BASED FUNCTIONAL PHENOTYPING ASSAY FOR DRUG-INDUCED CARDIOTOXICITY SCREENINGR01HL135143 · NHLBI · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2017 to 2021
$1.9M
A HUMAN IPSC-BASED 3D MICROPHYSIOLOGICAL SYSTEM FOR MODELING CARDIAC DYSFUNCTION IN MICROGRAVITYUG3EB028094 · NIBIB · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2018 to 2019
$1.5M
Mechanical regulation of CM proliferation and morphogenesisF32HL143851 · NHLBI · UNIVERSITY OF WASHINGTON · PI EL-NACHEF, DANNY · 2019 to 2020
$69k
Engineering human cardiac ventricles with controllable architecture for modeling dystrophic cardiomyopathyF31HL145809 · NHLBI · UNIVERSITY OF WASHINGTON · PI WILLIAMS, NISA P · 2019 to 2019
$33k
NHLBI NIH HHS DP2 HL137188NHLBI NIH HHS F31 HL145809NHLBI NIH HHS F32 HL143851NHLBI NIH HHS R01 HL135143NHLBI NIH HHS R01 HL141187NHLBI NIH HHS R01 HL141570NHLBI NIH HHS R01 HL142624NHLBI NIH HHS R01 HL146436NHLBI NIH HHS R01 HL149734NIBIB NIH HHS UG3 EB028094
6 · The paper itself

Abstract

Recent advances in stem cell biology and tissue engineering have laid the groundwork for building complex tissues in a dish. We propose that these technologies are ready for a new challenge: recapitulating cardiac morphogenesis in vitro. In development, the heart transforms from a simple linear tube to a four-chambered organ through a complex process called looping. Here, we re-examine heart tube looping through the lens of an engineer and argue that the linear heart tube is an advantageous starting point for tissue engineering. We summarize the structures, signaling pathways, and stresses in the looping heart, and evaluate approaches that could be used to build a linear heart tube and guide it through the process of looping.

Indexed as

Stem Cell TransplantationTissue EngineeringAnimalsHeartHumansMorphogenesisOrganogenesisSignal TransductionStem Cell ResearchStem Cellsbiomaterialsheart tube loopingmechanobiologyorganogenesisstem cellstissue engineering

Identifiers

PMID32673587
PMCPMC7368094
OpenAlexW3009352934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.