ArticleHypertension (Dallas, Tex. : 1979)2020
Redefining Cardiac Biomarkers in Predicting Mortality of Inpatients With COVID-19.
Abstract readMulticenter Study
In one paragraph
Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 4 of them syntheses that pooled it.
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0cells of the map it votes in
86citing papers in PubMed, 4 pooled it
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- The Impact of Frailty on COVID-19 Outcomes: A Systematic Review and Meta-analysis of 16 Cohort Studies.The journal of nutrition, health & aging · 2021Pooled it
- The Predictive Value of Myoglobin for COVID-19-Related Adverse Outcomes: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- B-Type Natriuretic Peptide Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression.Frontiers in cardiovascular medicine · 2021Pooled it
- Comparison of risk factors and outcomes of raised vs normal cardiac troponin levels in COVID-19 patients: a retrospective study.Scientific reports · 2025Article
- Omics for searching plasma biomarkers associated with unfavorable COVID-19 progression in hypertensive patients.Scientific reports · 2025Article
- Biochemical differences based on sex and clusters of biomarkers in patients with COVID-19: analysis from the CARDIO COVID 19-20 registry.BMC cardiovascular disorders · 2025Observational
- The prognostic role of cardiac and inflammatory biomarkers in extubation failure in patients with COVID-19 acute respiratory distress syndrome.Annals of intensive care · 2025Article
- Biomarkers for SARS-CoV-2 infection. A narrative review.Frontiers in medicine · 2025Review
- Correlation of troponin I and CK-MB with COVID-19 severity in seriously ill patients: A retrospective analysis from medical records.Bioinformation · 2025Article
- Long-term Cardiovascular Outcomes in Patients with Omicron COVID-19 and Elevated Cardiac Biomarkers: A Prospective Multicenter Cohort Study in Shanghai, China.International journal of medical sciences · 2025Article
- Beyond the Usual Features-Expanded Dengue Syndrome in Association With Possible Pre-existing Neurological Disease: A Case Report.Clinical medicine insights. Case reports · 2025Article
- Current Scenario in Associating Clinical COVID-19 Biomarkers for Developing Surveillance Platforms.Current medicinal chemistry · 2025Review
- Cardiac Damage in Patients Infected with Different SARS-CoV-2 Variants of Concern.Microorganisms · 2024Article
- The Role and Implications of COVID-19 in Incident and Prevalent Heart Failure.Current heart failure reports · 2024Review
- A multicenter study of asymmetric and symmetric dimethylarginine as predictors of mortality risk in hospitalized COVID-19 patients.Scientific reports · 2024Article
- Association of Abnormal Cardiac Biomarkers and Cardiovascular Complications, with Mortality in Patients with SARS-CoV-2 Infection in Latin America.Journal of cardiovascular development and disease · 2024Article
- Risk stratification and prognosis prediction using cardiac biomarkers in COVID-19: a single-centre retrospective cohort study.BMJ open · 2024Article
- Exploring in-hospital clinical outcomes among acute myocardial infarction patients with prior COVID-19 history.Journal of cardiovascular and thoracic research · 2024Article
- What can autopsy say about COVID-19? A case series of 60 autopsies.Legal medicine (Tokyo, Japan) · 2023Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors.
Juan-Juan Qin *From the Department of Cardiology (J.-J.Q.), Zhongnan Hospital of Wuhan University, China.
Xu Cheng *Department of Cardiology (J.-J.Q., X.C., X.-J.Z., J.X., Y.-M.L., L.L., M.-M.C., L.Z., Z.-G.S., H.L.), Renmin Hospital of Wuhan University, China.
Feng Zhou *Medical Science Research Center (F.Z., P.Z., H.L.), Zhongnan Hospital of Wuhan University, China.
Fang Lei *Basic Medical School, Wuhan University, China (F.L., Z.H., X.S., Z.C., X.Z., H.L.).
Gauri AkolkarDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ontario, Canada (G.A., A.B., P.P.L.).
Jingjing Cai
Xiao-Jing ZhangDepartment of Cardiology (J.-J.Q., X.C., X.-J.Z., J.X., Y.-M.L., L.L., M.-M.C., L.Z., Z.-G.S., H.L.), Renmin Hospital of Wuhan University, China.
Alice BletDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ontario, Canada (G.A., A.B., P.P.L.).
Jing XieDepartment of Cardiology (J.-J.Q., X.C., X.-J.Z., J.X., Y.-M.L., L.L., M.-M.C., L.Z., Z.-G.S., H.L.), Renmin Hospital of Wuhan University, China.
Peng ZhangMedical Science Research Center (F.Z., P.Z., H.L.), Zhongnan Hospital of Wuhan University, China.
Ye-Mao LiuDepartment of Cardiology (J.-J.Q., X.C., X.-J.Z., J.X., Y.-M.L., L.L., M.-M.C., L.Z., Z.-G.S., H.L.), Renmin Hospital of Wuhan University, China.
Zizhen HuangBasic Medical School, Wuhan University, China (F.L., Z.H., X.S., Z.C., X.Z., H.L.).
Ling-Ping ZhaoInstitute of Model Animal of Wuhan University, China (J.-J.Q., X.C., F.Z., F.L., X.-J.Z., P.Z., Y.-M.L., Z.H., L.-P.Z., L.L., M.X., M.-M.C., X.S., L.B., Z.C., X.Z., D.X., J. Chen, L.Z., Z.-G.S., H.L.).
Lijin LinDepartment of Cardiology (J.-J.Q., X.C., X.-J.Z., J.X., Y.-M.L., L.L., M.-M.C., L.Z., Z.-G.S., H.L.), Renmin Hospital of Wuhan University, China.
Meng XiaInstitute of Model Animal of Wuhan University, China (J.-J.Q., X.C., F.Z., F.L., X.-J.Z., P.Z., Y.-M.L., Z.H., L.-P.Z., L.L., M.X., M.-M.C., X.S., L.B., Z.C., X.Z., D.X., J. Chen, L.Z., Z.-G.S., H.L.).
Ming-Ming ChenDepartment of Cardiology (J.-J.Q., X.C., X.-J.Z., J.X., Y.-M.L., L.L., M.-M.C., L.Z., Z.-G.S., H.L.), Renmin Hospital of Wuhan University, China.
Xiaohui SongBasic Medical School, Wuhan University, China (F.L., Z.H., X.S., Z.C., X.Z., H.L.).
Liangjie BaiInstitute of Model Animal of Wuhan University, China (J.-J.Q., X.C., F.Z., F.L., X.-J.Z., P.Z., Y.-M.L., Z.H., L.-P.Z., L.L., M.X., M.-M.C., X.S., L.B., Z.C., X.Z., D.X., J. Chen, L.Z., Z.-G.S., H.L.).
Ze ChenBasic Medical School, Wuhan University, China (F.L., Z.H., X.S., Z.C., X.Z., H.L.).
Xingyuan ZhangBasic Medical School, Wuhan University, China (F.L., Z.H., X.S., Z.C., X.Z., H.L.).
Da XiangInstitute of Model Animal of Wuhan University, China (J.-J.Q., X.C., F.Z., F.L., X.-J.Z., P.Z., Y.-M.L., Z.H., L.-P.Z., L.L., M.X., M.-M.C., X.S., L.B., Z.C., X.Z., D.X., J. Chen, L.Z., Z.-G.S., H.L.).
Jing ChenInstitute of Model Animal of Wuhan University, China (J.-J.Q., X.C., F.Z., F.L., X.-J.Z., P.Z., Y.-M.L., Z.H., L.-P.Z., L.L., M.X., M.-M.C., X.S., L.B., Z.C., X.Z., D.X., J. Chen, L.Z., Z.-G.S., H.L.).
Qingbo XuCentre for Clinic Pharmacology, The William Harvey Research Institute, Queen Mary University of London, United Kingdom (Q.X.).
Xinliang MaDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania (X.M.).
Rhian M TouyzInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom (R.M.T.).
Chen GaoDepartment of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles (C.G., Y.W.).
Haitao WangDepartment of Hepatobiliary and Pancreatic Surgery (H.W., Y. Yuan), Zhongnan Hospital of Wuhan University, China.
Liming LiuDepartment of General Surgery, Ezhou Central Hospital, Wuhan, China (L.L.).
Weiming MaoDepartment of General Surgery, Huanggang Central Hospital, Wuhan, China (W.M.).
Pengcheng LuoDepartment of Urology (P.L.), Wuhan Third Hospital and Tongren Hospital of Wuhan University, China.
Youqin YanWuhan Seventh Hospital, China (Y. Yan).
Ping YeDepartment of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, China (P.Y., M.C.).
Manhua ChenDepartment of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, China (P.Y., M.C.).
Guohua ChenDepartment of Neurology, Wuhan First Hospital/Wuhan Hospital of Traditional Chinese and Western Medicine, Hubei, China (G.C.).
Lihua ZhuDepartment of Cardiology (J.-J.Q., X.C., X.-J.Z., J.X., Y.-M.L., L.L., M.-M.C., L.Z., Z.-G.S., H.L.), Renmin Hospital of Wuhan University, China.
Zhi-Gang SheDepartment of Cardiology (J.-J.Q., X.C., X.-J.Z., J.X., Y.-M.L., L.L., M.-M.C., L.Z., Z.-G.S., H.L.), Renmin Hospital of Wuhan University, China.
Xiaodong HuangDepartment of Gastroenterology (X.H.), Wuhan Third Hospital and Tongren Hospital of Wuhan University, China.
Yufeng YuanDepartment of Hepatobiliary and Pancreatic Surgery (H.W., Y. Yuan), Zhongnan Hospital of Wuhan University, China.
Bing-Hong ZhangDepartment of Neonatology (B.-H.Z.), Renmin Hospital of Wuhan University, China.
Yibin WangDepartment of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles (C.G., Y.W.).
Peter P Liu
Hongliang LiMedical Science Research Center (F.Z., P.Z., H.L.), Zhongnan Hospital of Wuhan University, China.
Funding
Novel Mechanism of RBFox1 Mediated RNA Metabolism in Heart FailureR00HL141626 · NHLBI · UNIVERSITY OF CINCINNATI · PI GAO, CHEN · 2022 to 2024
$747kA Systems Approach to Uncover Novel Genes and Networks in Heart FailureR21HL110667 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, WANG, YIBIN · 2011 to 2012
$424kNovel Mechanism of RBFox1 Mediated RNA Metabolism in Heart FailureK99HL141626 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GAO, CHEN · 2019 to 2021
$329kNHLBI NIH HHS K99 HL141626NHLBI NIH HHS R00 HL141626NHLBI NIH HHS R21 HL110667
Abstract
The prognostic power of circulating cardiac biomarkers, their utility, and pattern of release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 patients with diagnosed COVID-19 admitted to 9 hospitals from December 31, 2019 to March 4, 2020, to estimate the associations and prognostic power of circulating cardiac injury markers with the poor outcomes of COVID-19. In the mixed-effects Cox model, after adjusting for age, sex, and comorbidities, the adjusted hazard ratio of 28-day mortality for hs-cTnI (high-sensitivity cardiac troponin I) was 7.12 ([95% CI, 4.60-11.03]
Indexed as
Coronavirus InfectionsHeart DiseasesPandemicsPneumonia, ViralBetacoronavirusBiomarkersChinaCOVID-19Creatine Kinase, MB FormFemaleHospitalizationHumansMaleMiddle AgedMortalityNatriuretic Peptide, BrainBiomarkersCreatine Kinase, MB FormNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Troponin Ibiomarkersheart diseasesheart injuriesmortalityprognosis
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