ReviewACS chemical neuroscience2020
Anosmia in COVID-19: A Bumpy Road to Establishing a Cellular Mechanism.
Review in ACS chemical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05184192 (Efficacy of Gabapentin for Post-Covid-19 Olfactory Dysfunction), which is not on this map. Cited by 49 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Gabapentin for Post-Covid-19 Olfactory Dysfunction
Who cites it
49 citing papers in PubMed, 8 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction.The Cochrane database of systematic reviews · 2022Pooled it
- Interventions for the prevention of persistent post-COVID-19 olfactory dysfunction.The Cochrane database of systematic reviews · 2022Pooled it
- Neuroradiological Basis of COVID-19 Olfactory Dysfunction: A Systematic Review and Meta-Analysis.The Laryngoscope · 2022Pooled it
- A Systematic Review of Imaging Studies in Olfactory Dysfunction Secondary to COVID-19.Academic radiology · 2021Pooled it
- Interventions for the prevention of persistent post-COVID-19 olfactory dysfunction.The Cochrane database of systematic reviews · 2021Pooled it
- Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction.The Cochrane database of systematic reviews · 2021Pooled it
- Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences.ACS chemical neuroscience · 2020Pooled it
- Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review.Brazilian journal of otorhinolaryngologyPooled it
- Efficacy of Gabapentin For Post-COVID-19 Olfactory Dysfunction: The GRACE Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2023Trial
- Photobiomodulation, Transmucosal Laser Irradiation of Blood, or B complex as alternatives to treat Covid-19 Related Long-Term Taste Impairment: double-blind randomized clinical trial.Lasers in medical science · 2023Trial
- Impact of SARS-CoV-2 variants on COVID-19 symptomatology and severity during five waves.Heliyon · 2024Article
- Treatments for Olfactory Dysfunction in COVID-19: A Systematic Review.International archives of otorhinolaryngology · 2024Review
- Polyunsaturated Fatty Acids as Potential Treatments for COVID-19-Induced Anosmia.Biomedicines · 2024Review
- Article
- SARS-CoV-2 and Other Respiratory Viruses in Human Olfactory Pathophysiology.Microorganisms · 2024Review
- Article
- Alcohol Sniff Test (AST): An Important Tool for Screening Post-Viral Olfactory Loss in Acute Flu-Like Dysfunction.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Disrupted chromatin architecture in olfactory sensory neurons: looking for the link from COVID-19 infection to anosmia.Scientific reports · 2023Article
- The Latest Cellular and Molecular Mechanisms of COVID-19 on Non-Lung Organs.Brain sciences · 2023Review
- Autoimmunity, COVID-19 Omicron Variant, and Olfactory Dysfunction: A Literature Review.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has become clear since the pandemic broke out that SARS-CoV-2 virus causes reduction of smell and taste in a significant fraction of COVID-19 patients. The olfactory dysfunction often occurs early in the course of the disease, and sometimes it is the only symptom in otherwise asymptomatic carriers. The cellular mechanisms for these specific olfactory disturbances in COVID-19 are now beginning to be elucidated. Several very recent papers contributed to explaining the key cellular steps occurring in the olfactory epithelium leading to anosmia/hyposmia (collectively known as dysosmia) initiated by SARS-CoV-2 infection. In this Viewpoint, we discuss current progress in research on olfactory dysfunction in COVID-19 and we also propose an updated model of the SARS-CoV-2-induced dysosmia. The emerging central role of sustentacular cells and inflammatory processes in the olfactory epithelium are particularly considered. The proposed model of anosmia in COVID-19 does not answer unequivocally whether the new coronavirus exploits the olfactory route to rapidly or slowly reach the brain in COVID-19 patients. To answer this question, new systematic studies using an infectious virus and appropriate animal models are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.