ArticlePloS one2020
Whole fungal elicitors boost paclitaxel biosynthesis induction in Corylus avellana cell culture.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The effects of Fusarium graminearum cell extracts and culture filtrates on the production of paclitaxel and 10-deacetylbaccatin III in suspension cell cultures of Taxus baccata L.BMC plant biology · 2025Article
- Multilayer perceptron neural network-genetic algorithm for modeling Nicotiana tabacum leaf quality.PloS one · 2025Article
- Enhancement of anti-cancer compounds in fungal elicited-Oldenlandia umbellata culture.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Fungal endophytes of Taxus species and regulatory effect of two strains on taxol synthesis.BMC microbiology · 2024Article
- Paclitaxel - a Product of Fungal Secondary Metabolism or an Artefact?Planta medica · 2024Review
- Modifications in gene expression and phenolic compounds content by methyl jasmonate and fungal elicitors in Ficus carica. Cv. Siah hairy root cultures.BMC plant biology · 2024Article
- Culture-based diversity of endophytic fungi of three species ofFrontiers in microbiology · 2024Article
- Article
- Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation inJournal of fungi (Basel, Switzerland) · 2023Article
- Biosynthesized Ag nanoparticles on urea-based periodic mesoporous organosilica enhance galegine content in Galega.Applied microbiology and biotechnology · 2023Article
- Multilayer perceptron-genetic algorithm as a promising tool for modeling cultivation substrate of Auricularia cornea Native to Iran.PloS one · 2023Article
- Review
- Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels.Gels (Basel, Switzerland) · 2021Review
- Current Perspectives on Taxanes: Focus on Their Bioactivity, Delivery and Combination Therapy.Plants (Basel, Switzerland) · 2021Review
- Article
- Identification and in-silico characterization of taxadien-5α-ol-O-acetyltransferase (TDAT) gene in Corylus avellana L.PloS one · 2021Article
- Article
- Mathematical Modeling of Growth and Paclitaxel Biosynthesis inFrontiers in plant science · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paclitaxel is an effective natural-source chemotherapeutic agent commonly applied to treat a vast range of cancers. In vitro Corylus avellana culture has been reported as a promising and inexpensive system for paclitaxel production. Fungal elicitors have been made known as the most efficient strategy for the biosynthesis induction of secondary metabolites in plant in vitro culture. In this research, C. avellana cell suspension culture (CSC) was exposed to cell extract (CE) and culture filtrate (CF) derived from Camarosporomyces flavigenus, either individually or combined treatment, in mid and late log phase. There is no report on the use of whole fungal elicitors (the combined treatment of CE and CF) for the elicitation of secondary metabolite biosynthesis in plant in vitro culture. The combined treatment of CE and CF significantly led to more paclitaxel biosynthesis and secretion than the individual use of them. Also, multivariate statistical approaches including stepwise regression (SR), ordinary least squares regression (OLSR), principal component regression (PCR) and partial least squares regression (PLSR) were used to model and predict paclitaxel biosynthesis and secretion. Based on value account for (VAF), root mean square error (RMSE), coefficient of determination (R2), mean absolute percentage error (MAPE) and relative percent difference (RPD) can be concluded that mentioned regression models effectively worked only for modeling and predicting extracellular paclitaxel portion in C. avellana cell culture.
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