ArticleAging2020
Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Age-Related Macular Degeneration: Cellular and Molecular Signaling Mechanisms.International journal of molecular sciences · 2025Review
- Systemic C-reactive protein levels in patients with geographic atrophy stratified by sex.International journal of ophthalmology · 2025Article
- Sialylation as a checkpoint for inflammatory and complement-related retinal diseases.Frontiers in cellular neuroscience · 2025Review
- C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions.Frontiers in immunology · 2025Article
- The association between the C-reactive protein-to-albumin-to-lymphocyte index and retinopathy: insights from a population-based study.Frontiers in nutrition · 2025Article
- C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration.Frontiers in immunology · 2024Observational
- Discordance of Aqueous/Plasma HIV Replication on ART.Current HIV research · 2024Article
- Association of C-reactive protein and complement factor H gene polymorphisms with risk of lupus nephritis in Chinese population.World journal of clinical cases · 2023Article
- C-reactive protein deficiency ameliorates experimental abdominal aortic aneurysms.Frontiers in immunology · 2023Article
- Article
- C-reactive protein isoforms as prognostic markers of COVID-19 severity.Frontiers in immunology · 2022Article
- Monomeric C-Reactive Protein: Current Perspectives for Utilization and Inclusion as a Prognostic Indicator and Therapeutic Target.Frontiers in immunology · 2022Review
- Interlink between Inflammation and Oxidative Stress in Age-Related Macular Degeneration: Role of Complement Factor H.Biomedicines · 2021Review
- Exploring the role of inflammation in age-related macular degeneration: new insights and implications for future therapies.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retinal pigment epithelium (RPE) is considered one of the main targets of age-related macular degeneration (AMD), the leading cause of irreversible vision loss among the ageing population worldwide. Persistent low grade inflammation and oxidative stress eventually lead to RPE dysfunction and disruption of the outer blood-retinal barrier (oBRB). Increased levels of circulating pentameric C-reactive protein (pCRP) are associated with higher risk of AMD. The monomeric form (mCRP) has been detected in drusen, the hallmark deposits associated with AMD, and we have found that mCRP induces oBRB disruption. However, it is unknown how mCRP is generated in the subretinal space. Using a Transwell model we found that both pCRP and mCRP can cross choroidal endothelial cells and reach the RPE
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.