SynthesisJournal of medical Internet research2020
Effectiveness and Safety of Using Chatbots to Improve Mental Health: Systematic Review and Meta-Analysis.
Synthesis in Journal of medical Internet research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 21 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
170 citing papers in PubMed, 21 syntheses or guidelines pooled it.
- Effectiveness of Chatbots in Mental Health Screening and Assessment: Systematic Review.JMIR mental health · 2026Pooled it
- Usability and User Experience Assessment of Health Care Conversational Agents Using Validated Subjective Instruments: Systematic Review and Comparative Analysis.JMIR human factors · 2026Pooled it
- Therapeutic Interaction Features of AI Chatbots in Depression Interventions: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Efficacy, User Engagement, and Acceptability of Cognitive Behavioral Therapy-Oriented Psychological Chatbots for Adults With Depressive and/or Anxiety Symptoms: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Standalone commercial exergame training to improve balance in older adults in care facilities: a systematic review and meta-analysis of recent 10-year randomized controlled trials.BMC geriatrics · 2026Pooled it
- A systematic review of artificial intelligence in child and adolescent interventions: from psychotherapy to developmental support.European child & adolescent psychiatry · 2026Pooled it
- Chatbot interventions for improving mental health among people in Asia: a systematic review and meta-analysis of randomised controlled trials.BMJ health & care informatics · 2026Pooled it
- Human-like conversational agents as social partners: a scoping review of socioaffective mechanisms, well-being outcomes, risks and governance in the post-Turing era.Frontiers in artificial intelligence · 2026Pooled it
- The use of chatbots as interventions for mental health conditions: scoping review of systematic reviews and meta-analyses.Frontiers in digital health · 2026Pooled it
- The Effectiveness of AI Chatbots in Alleviating Mental Distress and Promoting Health Behaviors Among Adolescents and Young Adults: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Chatbot-Delivered Interventions for Improving Mental Health Among Young People: A Systematic Review and Meta-Analysis.Worldviews on evidence-based nursing · 2025Pooled it
- Effectiveness of AI-Driven Conversational Agents in Improving Mental Health Among Young People: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Effectiveness of Digital Lifestyle Interventions on Depression, Anxiety, Stress, and Well-Being: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Does the Digital Therapeutic Alliance Exist? Integrative Review.JMIR mental health · 2025Pooled it
- Unleashing the potential of chatbots in mental health: bibliometric analysis.Frontiers in psychiatry · 2025Pooled it
- A systematic review of artificial intelligence-powered (AI-powered) chatbot intervention for managing chronic illness.Annals of medicine · 2024Pooled it
- Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Guideline
- Patient Engagement with Conversational Agents in Health Applications 2016-2022: A Systematic Review and Meta-Analysis.Journal of medical systems · 2024Pooled it
- Conversational Agents for Body Weight Management: Systematic Review.Journal of medical Internet research · 2023Pooled it
- Artificial Intelligence-Based Chatbots for Promoting Health Behavioral Changes: Systematic Review.Journal of medical Internet research · 2023Pooled it
110 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe global shortage of mental health workers has prompted the utilization of technological advancements, such as chatbots, to meet the needs of people with mental health conditions. Chatbots are systems that are able to converse and interact with human users using spoken, written, and visual language. While numerous studies have assessed the effectiveness and safety of using chatbots in mental health, no reviews have pooled the results of those studies.
objectiveThis study aimed to assess the effectiveness and safety of using chatbots to improve mental health through summarizing and pooling the results of previous studies.
methodsA systematic review was carried out to achieve this objective. The search sources were 7 bibliographic databases (eg, MEDLINE, EMBASE, PsycINFO), the search engine "Google Scholar," and backward and forward reference list checking of the included studies and relevant reviews. Two reviewers independently selected the studies, extracted data from the included studies, and assessed the risk of bias. Data extracted from studies were synthesized using narrative and statistical methods, as appropriate.
resultsOf 1048 citations retrieved, we identified 12 studies examining the effect of using chatbots on 8 outcomes. Weak evidence demonstrated that chatbots were effective in improving depression, distress, stress, and acrophobia. In contrast, according to similar evidence, there was no statistically significant effect of using chatbots on subjective psychological wellbeing. Results were conflicting regarding the effect of chatbots on the severity of anxiety and positive and negative affect. Only two studies assessed the safety of chatbots and concluded that they are safe in mental health, as no adverse events or harms were reported.
conclusionsChatbots have the potential to improve mental health. However, the evidence in this review was not sufficient to definitely conclude this due to lack of evidence that their effect is clinically important, a lack of studies assessing each outcome, high risk of bias in those studies, and conflicting results for some outcomes. Further studies are required to draw solid conclusions about the effectiveness and safety of chatbots.
trial registrationPROSPERO International Prospective Register of Systematic Reviews CRD42019141219; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019141219.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.