ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2020
Chronic Comorbidities Among Survivors of Adolescent and Young Adult Cancer.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
124 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Behavior change techniques in physical activity and dietary interventions among adolescent and young adult cancer survivors: a systematic review and meta-analysis of randomized controlled trials.Journal of cancer survivorship : research and practice · 2026Pooled it
- Fertility preservation access among female adolescents and young adults with cancer: A systematic review.Cancer · 2026Pooled it
- Sexual health outcomes among adolescent and young adult cancer patients: a systematic review and meta-analysis.JNCI cancer spectrum · 2023Pooled it
- A systematic review of health-related quality of life outcomes in psychosocial intervention trials for adolescent and young adult cancer survivors.Critical reviews in oncology/hematology · 2023Pooled it
- Survival After Diagnosis of Cardiovascular Disease in Survivors of Adolescent and Young Adult Lymphoma.European journal of haematology · 2026Article
- Article
- Article
- Are age and sex associated with variation in use of follow-up care and financial barriers to care in U.S. cancer survivors?Journal of cancer survivorship : research and practice · 2026Article
- Adolescents and young adults living with and beyond cancer.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Transitions Within and Use of Outpatient Primary and Oncology Care in Survivors of Adolescent and Young Adult-Onset Cancers.JCO oncology practice · 2026Article
- Cancer Screening Uptake and Usual Source of Care Among Hispanic Survivors of Adolescent and Young Adult Cancer.Journal of adolescent and young adult oncology · 2026Article
- Associations between Ambient Air Pollution and Cardiovascular and Respiratory Healthcare Visits in Adolescent and Young Adult Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Clinical Practice Guidelines for the Care of Adolescents and Young Adults (AYAs) with Cancer: a Scoping Review.Current oncology reports · 2026Article
- Health Priorities and Intervention Preferences among Young Adult Cancer Survivors: A Mixed-Methods Study.Journal of adolescent and young adult oncology · 2026Article
- Hospitalization for medical conditions in adolescent and young adult cancer survivors: a nationwide cohort study using the Netherlands Cancer Registry.Journal of cancer survivorship : research and practice · 2026Article
- "Nothing Is as Great a Learning Experience as Getting a $15,000 Bill": A Mixed-Methods Study of Young Adult Cancer Survivors' Experience With Insurance Coverage.JCO oncology practice · 2026Article
- Increased Incidence of De Novo Malignancies Compared With Malignancy Recurrences in Survivors of Cancer Undergoing Heart Transplantation.Journal of the American Heart Association · 2026Article
- Review
- Weight-Related Outcomes Among Survivors of Adolescent and Young Adult Cancer after Anti-Obesity Medication Initiation.Journal of adolescent and young adult oncology · 2026Article
- Hospitalisations and Costs of Chronic Health Conditions Among Long-Term Survivors of Childhood, Adolescent, and Young Adult Cancers in Queensland, Australia.Psycho-oncology · 2026Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeTo describe the incidence, relative risk, and risk factors for chronic comorbidities in survivors of adolescent and young adult (AYA) cancer.
methodsThis retrospective cohort study included 2-year survivors of AYA cancer diagnosed between age 15 and 39 years at Kaiser Permanente Southern California from 2000 to 2012. A comparison cohort without cancer was individually matched (13:1) to survivors of cancer on age, sex, and calendar year. Using electronic medical records, all participants were followed through December 31, 2014, for chronic comorbidity diagnoses. Poisson regression was used to evaluate the association between cancer survivor status and risk of developing each comorbidity. The associations between cumulative exposure to chemotherapy and radiation therapy and selected comorbidities were examined for survivors of cancer.
resultsThe cohort included 6,778 survivors of AYA cancer and 87,737 persons without a history of cancer. The incidence rate ratio (IRR) for survivors of cancer was significantly increased for nearly all comorbidities examined. IRR ranged from 1.3 (95% CI, 1.2 to 1.4) for dyslipidemia to 8.3 (95% CI, 4.6 to 14.9) for avascular necrosis. Survivors of AYA cancer had a 2- to 3-fold increased risk for cardiomyopathy, stroke, premature ovarian failure, chronic liver disease, and renal failure. Among survivors of cancer, significant associations between chemotherapy and radiation therapy exposures and late effects of cardiomyopathy, hearing loss, stroke, thyroid disorders, and diabetes were observed from the multivariable analyses. Forty percent of survivors of AYA cancer had multiple (≥ 2) comorbidities at 10 years after index date, compared with 20% of those without cancer.
conclusionRisk of developing comorbidities is increased in survivors of AYA cancer compared with the general population. Specific cancer treatment exposures were associated with risk of developing different comorbidities. These findings have important implications for survivorship care planning and patient education.
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