Trial reportAmerican journal of respiratory and critical care medicine2021
Chemokine Receptor 2-targeted Molecular Imaging in Pulmonary Fibrosis. A Clinical Trial.
Open access · greenAbstract readClinical TrialComparative Study
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- The Role of Monocytes in the Natural History of Idiopathic Pulmonary Fibrosis: A Systematic Literature Review.International journal of molecular sciences · 2025Pooled it
- Collagenase-Coated Polymeric Drug/siRNA Nanoparticles Overcome ECM and Regulate Metabolic Reprogramming of Fibroblasts for Alleviating Pulmonary Fibrosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Integrated Cytokine and Immune Cell Profiling Reveals a Distinct Immune Signature Associated with High-Altitude Pulmonary Edema.International journal of molecular sciences · 2026Article
- Assessment of CCR2 PET as a Biomarker for Head and Neck Squamous Cell Carcinoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Molecular imaging of immune and fibrosis targets to guide therapy for repair after myocardial infarction.Nature reviews. Cardiology · 2026Review
- Immunological mechanisms and therapeutic approaches in pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Review
- Monocyte-mediated mechanisms in idiopathic pulmonary fibrosis: opportunities for early intervention.Apoptosis : an international journal on programmed cell death · 2026Review
- Macrophages and TGFB signaling regulate fibrosis in theAmerican journal of physiology. Renal physiology · 2026Article
- Unraveling the pleiotropic effects of CCR2-dependent signal transduction in fibrosis development.Theranostics · 2026Review
- S100A8Frontiers in immunology · 2026Article
- Recruited Monocyte-Derived Macrophages Drive T Cell Inflammation in Immune Checkpoint Inhibitor-Mediated Pneumonitis.Cancer communications (London, England) · 2026Article
- Elucidating a Myofibroblast-dominated Fibrotic Niche in Crohn's Disease-associated Fibrostenosis Through High-resolution Spatial Transcriptomics.Cellular and molecular gastroenterology and hepatology · 2026Article
- Composition and Influence of Fibrogenic Niche in Myocardial Fibrosis.Reviews in cardiovascular medicine · 2026Review
- Personalized Medicine for Systemic Sclerosis-Associated Interstitial Lung Disease.Current treatment options in rheumatology · 2025Article
- The spatial and temporal activation of macrophages during fibrosis.Nature reviews. Immunology · 2025Review
- Pulmonary Fibrosis-Focusing on the Future: Aspen Lung Conference 2024 Summary.American journal of respiratory cell and molecular biology · 2025Article
- Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis.Respiratory research · 2025Article
- Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms.JACC. Basic to translational science · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
27 authors at 3 institutions in 2 countries.
Steven L BrodyDepartment of Medicine.ORCID 0000-0002-0905-7527
Sean P GunstenDepartment of Medicine.
Hannah P LuehmannDepartment of Radiology.
Debbie H SultanDepartment of Radiology.
Michelle HoelscherDepartment of Radiology.
Gyu Seong HeoDepartment of Radiology.
Jiehong PanDepartment of Medicine.
Jeffrey R KoenitzerDepartment of Medicine.
Ethan C LeeDepartment of Medicine.
Tao HuangDepartment of Medicine.
Cedric MpoyDepartment of Radiation Oncology.
Shuchi GuoDepartment of Medicine.
Richard LaforestDepartment of Radiology.
Amber SalterDivision of Biostatistics.
Tonya D RussellDepartment of Medicine.
Adrian ShifrenDepartment of Medicine.
Christophe CombadiereINSERM, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Sorbonne Université, Paris, France.
Kory J LavineDepartment of Medicine.
Daniel KreiselDepartment of Surgery, and.
Benjamin D HumphreysDepartment of Medicine.
Buck E RogersDepartment of Radiation Oncology.
David S GieradaDepartment of Radiology.
Derek E ByersDepartment of Medicine.
Robert J GroplerDepartment of Medicine.
Delphine L ChenDepartment of Radiology.
Jeffrey J AtkinsonDepartment of Medicine.
Yongjian LiuDepartment of Radiology.
Cancer Research And Biostatistics · USInserm · FRWashington University in St. Louis · US
Funding
PRINCIPLES IN PULMONARY RESEARCHT32HL007317 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, Michael J Holtzman · 1985 to 2026
$16.1MTraining/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7MWashington University Center for Translational NeuroscienceP30NS057105 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2006 to 2011
$8.7MTargeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1MPURCHASE OF A SIEMENS NEXT GENERATION PET/CTS10OD025214 · OD · WASHINGTON UNIVERSITY · PI WOODARD, PAMELA K · 2018 to 2018
$2.0MPET IMAGING CCR2 IN LUNG INFLAMMATIONR01HL131908 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN, LIU, YONGJIAN · 2016 to 2018
$2.0MMACROPHAGE HETEROGENEITY IN HEART FAILURE PROGRESSION AND CARDIAC RECOVERYR01HL138466 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2017 to 2021
$1.9MMACROPHAGE ONTOGENY SHIFTS IN ISCHEMIC HEART DISEASER01HL139714 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2018 to 2021
$1.5MPURCHASE OF AN IMAGE-GUIDED SMALL-ANIMAL IRRADIATORS10OD020136 · OD · WASHINGTON UNIVERSITY · PI HALLAHAN, DENNIS E · 2015 to 2015
$600kNHLBI NIH HHS R01 HL131908NHLBI NIH HHS R01 HL138466NHLBI NIH HHS R01 HL139714NHLBI NIH HHS R35 HL145212NHLBI NIH HHS T32 HL007317NIBIB NIH HHS P41 EB025815NIH HHS S10 OD020136NIH HHS S10 OD025214NINDS NIH HHS P30 NS057105
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedAged, 80 and overAnimalsBiomarkersDisease Models, AnimalFemaleHumansIdiopathic Pulmonary FibrosisLungMacrophagesMaleMiceMiddle AgedMolecular ImagingMonocytesBiomarkersReceptors, CCR2CCR2macrophagesmonocytespositron emission tomographypulmonary fibrosis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.