Evidence map›Paper›PMID 32672536›Full record

ArticleeLife2020

Trait-associated noncoding variant regions affect

Jan Hendrik van Weerd, Rajiv A Mohan, Karel van Duijvenboden, Ingeborg B Hooijkaas, Vincent Wakker, Bastiaan J Boukens, Phil Barnett, Vincent M Christoffels

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. How Cardiac Embryology Translates into Clinical Arrhythmias.Journal of cardiovascular development and disease · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jan Hendrik van WeerdDepartment of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.ORCID 0000-0001-7955-8477
Rajiv A MohanDepartment of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.ORCID 0000-0002-3622-1759
Karel van DuijvenbodenDepartment of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Ingeborg B HooijkaasDepartment of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Vincent WakkerDepartment of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Bastiaan J BoukensDepartment of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Phil BarnettDepartment of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Vincent M ChristoffelsDepartment of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.ORCID 0000-0003-4131-2636
Amsterdam University Medical Centers · NL

Funding

Dutch Heart Foundation 2016T047Dutch Heart Foundation COBRA3Dutch Heart Foundation CVON project CONCOR genesFondation Leducq 14CVD01
6 · The paper itself

Abstract

Genome-wide association studies have implicated common genomic variants in the gene desert upstream of

Indexed as

T-Box Domain ProteinsAnimalsArrhythmias, CardiacGene Expression Regulation, DevelopmentalGenome-Wide Association StudyGenomicsHeart Conduction SystemHeart RateHumansMiceMice, TransgenicPolymorphism, Single NucleotideT-Box Domain ProteinsTBX3 protein, humanTbx3 protein, mouseatrioventricular conduction systemchromosomesCRISPR/Cas9E. colienhancerepigenomicsgene expressiongeneticsgenomicsmouseSNPtranscriptional regulation

Identifiers

PMID32672536
PMCPMC7365664
OpenAlexW3043339430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.