Evidence map›Paper›PMID 32672484›Full record

ArticleActa oncologica (Stockholm, Sweden)2020

Molecular genetic changes in solid pseudopapillary neoplasms (SPN) of the pancreas.

Elisa Rodriguez-Matta, Amanda Hemmerich, Jason Starr, Kabir Mody, Eric A Severson, Gerardo Colon-Otero

Abstract readLetter
In one paragraph

Article in Acta oncologica (Stockholm, Sweden), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  10. Review
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  15. Pediatric Solid Pseudopapillary Neoplasm of the Pancreas.Journal of Indian Association of Pediatric Surgeons
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elisa Rodriguez-MattaMS-2, Mayo Clinic CCATS Research Scholar, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
Amanda HemmerichFoundation Medicine, Morrisville, NC, USA.
Jason StarrDivision of Hematology Oncology, Mayo Clinic, Jacksonville, FL, USA.
Kabir ModyDivision of Hematology Oncology, Mayo Clinic, Jacksonville, FL, USA.
Eric A SeversonFoundation Medicine, Morrisville, NC, USA.
Gerardo Colon-OteroDivision of Hematology Oncology, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0002-9159-2421

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
NCATS NIH HHS UL1 TR002377NCI NIH HHS N01 CA015083NCI NIH HHS P30 CA015083
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Point MutationAdolescentAdultAgedAged, 80 and overbeta CateninChildCystadenocarcinoma, PapillaryFemaleGenes, p16HumansMaleMiddle AgedPancreatic NeoplasmsYoung Adultbeta CateninCTNNB1 protein, humaneach in 29% of the casesmost commonly in positions 32 and 37. Additional pathogenic mutations in other cancer associated genes are commonpresent in 64% of our cases. Comprehensive genomic profiling identified potentially actionable genomic alterations and mutations in DNA repair genesSolid pseudopapillary neoplasms of the pancreas are commonly associated with pathogenic point mutations in the CTNNB1 gene. Our series identified CTNNB1 mutations in 93% of the cases

Identifiers

PMID32672484
PMCPMC8081262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.