ArticleCancer reports (Hoboken, N.J.)2020
Higher dietary acid load is not associated with risk of breast cancer in Iranian women.
Article in Cancer reports (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Association of High Dietary Acid Load With the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in nutrition · 2022Pooled it
- Association between dietary acid load and cancer risk and prognosis: An updated systematic review and meta-analysis of observational studies.Frontiers in nutrition · 2022Pooled it
- Dietary acid load and the odds of knee osteoarthritis: a case-control study.Scientific reports · 2025Article
- The association between dietary acid load and odds of prostate cancer: a case-control study.Journal of health, population, and nutrition · 2025Article
- Relationship Between Dietary Acid Load and Risk of Metastatic Colorectal Cancer: A Case-Control Study.Current therapeutic research, clinical and experimental · 2025Article
- Dietary Acid Load, Serum Polychlorinated Biphenyl Levels, and Mortality Following Breast Cancer in the Long Island Breast Cancer Study Project.International journal of environmental research and public health · 2021Article
- Higher dietary acid load is not associated with risk of breast cancer in Iranian women.Cancer reports (Hoboken, N.J.) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDietary acid load (DAL) may play a key role in certain cancers, including breast cancer (BC); however, evidence showing a causal relationship is lacking.
aimWe examined the relationship between DAL, assessed with both the potential renal acid load (PRAL) and the net endogenous acid production (NEAP) scores, and BC risk.
methodsWe identified 150 women who had a diagnosis of BC recently and 150 age-matched apparently healthy controls. Data from dietary intake and anthropometric measures were collected from participants and eventually, PRAL and NEAP scores were obtained from nutrient intakes. Multivariate odds ratios (OR) with 95% confidence intervals (CI) were used to evaluate the relationship of BC risk with PRAL and NEAP scores.
resultsThe odds ratios (OR) of BC according to tertiles of PRAL and NEAP scores by multivariate logistic regression models revealed that both PRAL (P-trend = 0.8) and NEAP (P-trend = 0.1) scores were not significantly associated with BC risk. After controlling confounders, multiple logistic regressions still remained non-significant which indicated no significant associations between PRAL (P-trend = 0.9), NEAP (P-trend = 0.4) scores and risk of BC.
conclusionThe results of our study suggested that there is no significant relationship between DAL and BC incidence among Iranian women.
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