ReviewBritish journal of pharmacology2020
Targeting zinc metalloenzymes in coronavirus disease 2019.
Review in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial.International journal of environmental research and public health · 2022Trial
- Metal-binding proteins and proteases in RNA viruses: unravelling functional diversity and expanding therapeutic horizons.Journal of virology · 2023Article
- Epstein-Barr virus-acquired immunodeficiency in myalgic encephalomyelitis-Is it present in long COVID?Journal of translational medicine · 2023Review
- Zinc status in public health: exploring emerging research trends through bibliometric analysis of the historical context from 1978 to 2022.Environmental science and pollution research international · 2023Review
- A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound.Bioactive materials · 2023Article
- Role of Micronutrients and Gut Microbiota-Derived Metabolites in COVID-19 Recovery.International journal of molecular sciences · 2022Review
- The zinc proteome of SARS-CoV-2.Metallomics : integrated biometal science · 2022Article
- Major trace elements and their binding proteins in the early phase of Covid-19 infection.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Article
- Zn-Induced Interactions Between SARS-CoV-2 orf7a and BST2/Tetherin.ChemistryOpen · 2021Article
- Liver disorders in COVID-19, nutritional approaches and the use of phytochemicals.World journal of gastroenterology · 2021Review
- The role of micronutrient and immunomodulation effect in the vaccine era of COVID-19.Journal of the Chinese Medical Association : JCMA · 2021Review
- Article
- Immunopharmacological perspective on zinc in SARS-CoV-2 infection.International immunopharmacology · 2021Review
- Associations of essential and toxic metals/metalloids in whole blood with both disease severity and mortality in patients with COVID-19.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review.Bio-design and manufacturing · 2021Review
- Zinc.Advances in food and nutrition research · 2021Review
- How Zinc-Binding Systems, Expressed by Human Pathogens, Acquire Zinc from the Colonized Host Environment: A Critical Review on Zincophores.Current medicinal chemistry · 2021Review
- Targeting zinc metalloenzymes in coronavirus disease 2019.British journal of pharmacology · 2020Review
- Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framework.Nutrients · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence support a link between the essential element zinc and the coronavirus disease 2019 (COVID-19). An important fact is that zinc is present in proteins of humans and of viruses. Some zinc sites in viral enzymes may serve as drug targets and may liberate zinc ions, thus leading to changes in intracellular concentration of zinc ions, while increased intracellular zinc may induce biological effects in both the host and the virus. Drugs such as chloroquine may contribute to increased intracellular zinc. Moreover, clinical trials on the use of zinc alone or in addition to other drugs in the prophylaxis/treatment of COVID-19 are ongoing. Thereby, we aim to discuss the rationale for targeting zinc metalloenzymes as a new strategy for the treatment of COVID-19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.