Evidence map›Paper›PMID 32671696›Full record

ArticleJournal of molecular neuroscience : MN2021

Expression of G9a in Auditory Cortex Is Downregulated in a Rat Model of Age-Related Hearing Loss.

Qian Li, Yang-Hong Xiang, Xiao-Jun Liang, Yun Zhang, Peng-Peng Zhao, Min Wang, Xiao-Min Bao, Xian-Bai Zhu, An-Chun Deng

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Epigenetics, DNA damage, and aging.The Journal of clinical investigation · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Qian LiDepartment of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Yang-Hong XiangDepartment of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xiao-Jun LiangDepartment of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Yun ZhangDepartment of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Peng-Peng ZhaoDepartment of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Min WangDepartment of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xiao-Min BaoDepartment of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xian-Bai ZhuDepartment of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
An-Chun DengDepartment of Otolaryngology Head and Neck Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. 260019300@qq.com.ORCID http://orcid.org/0000-0003-4595-7597
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G9a is essential for dendritic plasticity and is associated with neurological disorders. The possible relationship between age-related hearing loss and G9a expression in the auditory cortex has not been fully explored. This study aimed to understand the expression patterns of G9a-mediated histone methylations in the auditory cortex during aging. Using immunofluorescence and western blotting, we demonstrated that a significant reduction in G9a expression observed in the auditory cortex of 24-month-old rats compared to 3-month-old rats, was associated with remarkable hearing threshold elevation and hair cell loss. Correspondingly, histone H3 lysine 9 (H3K9) mono- and dimethylation (marked by H3K9me1 and H3K9me2, respectively), which were regulated by G9a activity, also evidently decreased during aging. These findings, which merit further investigation, suggest a possible association between G9a-mediated histone methylations and central age-related hearing disorders.

Indexed as

AgingAnimalsAuditory CortexAuditory ThresholdDown-RegulationGene Expression RegulationHair Cells, AuditoryHistone CodeHistone-Lysine N-MethyltransferaseHistonesMaleMethylationModels, AnimalNerve Tissue ProteinsPresbycusisProtein Processing, Post-TranslationalEhmt2 protein, ratHistone-Lysine N-MethyltransferaseHistonesNerve Tissue ProteinsAgingAuditory cortexG9aHearing lossHistone methylations

Identifiers

PMID32671696
OpenAlexW3042658708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.