Evidence map›Paper›PMID 32671688›Full record

ReviewMolecular neurobiology2020

Current Status of Multiple Drug Molecules, and Vaccines: An Update in SARS-CoV-2 Therapeutics.

Ramesh Kandimalla, Albin John, Chandrika Abburi, Jayalakshmi Vallamkondu, P Hemachandra Reddy

Registry-linked trialAbstract readReview
In one paragraph

Review in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05081271 (COVID-19 Booster Vaccination in Persons With Multiple Sclerosis), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05081271 early_phase1terminatednot on this mapstarted 2021, after this paper: background citation

COVID-19 Booster Vaccination in Persons With Multiple Sclerosis

TypeinterventionalSponsorGriffin HospitalRan2021 to 2022Enrolled10ConditionsMultiple SclerosisArmsHomologous booster, Heterologous booster
3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Exploration ofChemical physics · 2021
    Article
  14. GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ramesh KandimallaDepartment of Biochemistry, Kakatiya Medical College, Warangal, Telangana, 506007, India.
Albin JohnInternal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Chandrika AbburiUniversity of Chicago, Chicago, IL, 60637, USA.
Jayalakshmi VallamkonduNational Institute of Technology, Warangal, Telangana, 506004, India.
P Hemachandra ReddyInternal Medicine, Neuroscience & Pharmacology, Texas Tech University Health Sciences Center, Lubbock, TX, USA. hemachandra.reddy@ttuhsc.edu.ORCID http://orcid.org/0000-0002-9560-9948

Funding

Dynamin-Related Protein 1 and Mitochondrial Fragmentation in Alzheimer's DiseaseR01AG042178 · NIA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI REDDY, P. HEMACHANDRA · 2012 to 2016
$2.0M
Voltage-Dependent Anion Channel and Neurodegeneration in Alzheimer's DiseaseR01AG047812 · NIA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI REDDY, P. HEMACHANDRA · 2014 to 2018
$1.9M
Mitochondrial Fragmentation and Neurodegeneration in Huntington's DiseaseR01NS105473 · NINDS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI REDDY, P. HEMACHANDRA · 2017 to 2021
$1.8M
Small Molecules as Therapeutic Targets for Alzheimer's DiseaseR56AG060767 · NIA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI REDDY, P. HEMACHANDRA · 2019 to 2019
$699k
NIA NIH HHS R01 AG042178NIA NIH HHS R01 AG047812NIA NIH HHS R56 AG060767NINDS NIH HHS R01 NS105473U.S. Department of Health and Human Services R01AG042178, R01AG47812, R01NS105473, and AG060767
6 · The paper itself

Abstract

The coronavirus disease of 2019 (COVID-19) is a pandemic disease that has taken the lives of many around the world. It is caused by severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2). To date, the USA, Italy, Spain, France, Russia, and the UK have been hit the hardest by the virus. However, death counts are still rising. Some nations have managed to "flatten" the death rate via protective measures such physical distancing, quarantine measures, and therapeutic management. The structure of the SARS-CoV-2 virus comprises of S proteins, M proteins, E proteins, hemagglutinin esterases, nucleocapsid proteins, and a 30-kb RNA genome. Viral proteases cleave these polyproteins and RNA-dependent polymerases replicate the genome. Currently, there are no effective therapies against this new disease. Numerous investigators are developing novel protease inhibitors, some of which have made it into clinical trials. Researchers are also attempting to develop a vaccine. In this review paper, we discuss the latest therapeutic developments against COVID-19. Graphical Abstract.

Indexed as

Antiviral AgentsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 VaccinesHumansPandemicsPneumonia, ViralProtease InhibitorsSARS-CoV-2Viral VaccinesAntiviral AgentsCOVID-19 VaccinesProtease InhibitorsViral VaccinesHCQProtease inhibitorRemdesivirSARS-CoV-2Vaccines

Identifiers

PMID32671688
PMCPMC7360695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.