Evidence map›Paper›PMID 32671623›Full record

ArticleMolecular biology reports2020

Frequency of the TP53 p.R337H mutation in a Brazilian cohort of pediatric patients with solid tumors.

José Antonio da Silva Feitosa, Pablo Ferreira das Chagas, Graziella Ribeiro de Sousa, Rosane Gomes de Paula Queiroz, Gustavo Alencastro Veiga Cruzeiro, Luiz Gonzaga Tone, Kleiton Silva Borges, Elvis Terci Valera

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Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

José Antonio da Silva FeitosaDepartment of Pediatrics, University of São Paulo, Ribeirão Preto, Brasil.
Pablo Ferreira das ChagasDepartment of Genetics Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brasil.
Graziella Ribeiro de SousaDepartment of Genetics Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brasil.
Rosane Gomes de Paula QueirozDepartment of Pediatrics, University of São Paulo, Ribeirão Preto, Brasil.
Gustavo Alencastro Veiga CruzeiroDepartment of Pediatrics, University of São Paulo, Ribeirão Preto, Brasil.
Luiz Gonzaga Tone *Department of Pediatrics, University of São Paulo, Ribeirão Preto, Brasil.
Kleiton Silva Borges *Department of Pediatrics, University of São Paulo, Ribeirão Preto, Brasil. kleiton.silvaborges@childrens.harvard.edu.ORCID https://orcid.org/0000-0003-0356-922X
Elvis Terci ValeraDepartment of Pediatrics, University of São Paulo, Ribeirão Preto, Brasil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 457884/2014-2Fundação de Amparo à Pesquisa do Estado de São Paulo 14/20341-0
6 · The paper itself

Abstract

TP53 p.R337H germline mutation is highly prevalent in the Southern region of Brazil. We sought to investigate TP53 p.R337H mutation in pediatric tumor samples from a population settled in a geographic area of high prevalence for this variant. Mutation assessment and genetic counseling for carriers/relatives were provided. 6/57 tumor samples were heterozygous for TP53 p.R337H. As expected, a high frequency was observed within adrenocortical tumors (3/3) and choroid plexus carcinomas (2/2). Interestingly, the TP53 R337H mutation was found in one case of pediatric rhabdomyosarcoma with Li-Fraumeni pedigree. Our finding expands the spectrum of childhood cancer associated with this germline mutation.

Indexed as

Germ-Line MutationAdrenal Cortex NeoplasmsBrazilCarcinomaChild, PreschoolChoroid Plexus NeoplasmsCohort StudiesFemaleHumansMaleMutation RateNeoplasmsPoint MutationRhabdomyosarcomaTumor Suppressor Protein p53TP53 protein, humanTumor Suppressor Protein p53Li–Fraumeni syndromePediatric cancerRhabdomyosarcomaTumor genetics

Identifiers

PMID32671623

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.