Evidence map›Paper›PMID 32671617›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2020

Health-related quality of life after traumatic brain injury: deriving value sets for the QOLIBRI-OS for Italy, The Netherlands and The United Kingdom.

Daphne C Voormolen, Suzanne Polinder, Nicole von Steinbuechel, Yan Feng, Lindsay Wilson, Mark Oppe, Juanita A Haagsma, CENTER-TBI participants and investigators

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06163833 (MATRIx), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06163833 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

MATRIx: MesenchymAl Stromal Cells for Traumatic bRain Injury

TypeinterventionalSponsorFondazione IRCCS San Gerardo dei TintoriRan2023 to 2026Enrolled78ConditionsTraumatic Brain Injury With Loss of ConsciousnessArmsMesenchymal stromal cell low dosage-80*10^6 cells, Mesenchymal stromal cell low dosage-160*10^6 cells, Placebo-storage solution
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 15 institutions in 11 countries.

Daphne C VoormolenDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. d.voormolen@erasmusmc.nldd.ORCID http://orcid.org/0000-0003-0449-0708
Suzanne PolinderDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Nicole von SteinbuechelInstitute of Medical Psychology and Medical Sociology, Georg-August-University, Waldweg 37, 37073, Göttingen, Germany.
Yan FengCentre for Primary Care and Public Health, Queen Mary University of London, London, UK.
Lindsay WilsonDepartment of Psychology, University of Stirling, Stirling, UK.
Mark OppeAxentiva Solutions, C/Calvario, 271-B 1º IZQ, Tacoronte, 38350, Santa Cruz de Tenerife, Spain.
Juanita A HaagsmaDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
CENTER-TBI participants and investigators
Radboud University Nijmegen · NLUniversity of Szeged · HUVita-Salute San Raffaele University · ITErasmus MC · NLUniversity of Stirling · GBInnsbruck Medical University · ATQueen Mary University of London · GBUniversity of Cambridge · GBMedical University of Vienna · ATUniversity Hospital of North Norway · NOCentre Hospitalier Régional et Universitaire de Nancy · FRCentre Hospitalier Universitaire de Grenoble · FRUniversitätsmedizin Göttingen · DEUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversity of Göttingen · DE

Funding

Seventh Framework Programme 602150
6 · The paper itself

Abstract

purposeThe Quality of Life after Brain Injury overall scale (QOLIBRI-OS) measures health-related quality of life (HRQoL) after traumatic brain injury (TBI). The aim of this study was to derive value sets for the QOLIBRI-OS in three European countries, which will allow calculation of utility scores for TBI health states.

methodsA QOLIBRI-OS value set was derived by using discrete choice experiments (DCEs) and visual analogue scales (VAS) in general population samples from the Netherlands, United Kingdom and Italy. A three-stage procedure was used: (1) A selection of health states, covering the entire spectrum of severity, was defined; (2) General population samples performed the health state valuation task using a web-based survey with three VAS questions and an at random selection of sixteen DCEs; (3) DCEs were analysed using a conditional logistic regression and were then anchored on the VAS data. Utility scores for QOLIBRI-OS health states were generated resulting in estimates for all potential health states.

resultsThe questionnaire was completed by 13,623 respondents. The biggest weight increase for all attributes is seen from "slightly" to "not at all satisfied", resulting in the largest impact on HRQoL. "Not at all satisfied with how brain is working" should receive the greatest weight in utility calculations in all three countries.

conclusionBy transforming the QOLIBRI-OS into utility scores, we enabled the application in economic evaluations and in summary measures of population health, which may be used to inform decision-makers on the best interventions and strategies for TBI patients.

Indexed as

AdolescentAdultAgedBrain Injuries, TraumaticFemaleHumansItalyMaleMiddle AgedNetherlandsQuality of LifeSurveys and QuestionnairesUnited KingdomYoung AdultHealth-related quality of lifeHealth utilitiesQuality of life after brain injury overall scale (QOLIBRI-OS)Traumatic brain injuryValue set

Identifiers

PMID32671617
PMCPMC7591447
OpenAlexW3043630591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.