Evidence map›Paper›PMID 32671341›Full record

ArticleBrain communications2020

Progressive dysexecutive syndrome due to Alzheimer's disease: a description of 55 cases and comparison to other phenotypes.

Ryan A Townley, Jonathan Graff-Radford, William G Mantyh, Hugo Botha, Angelina J Polsinelli, Scott A Przybelski, Mary M Machulda, Ahmed T Makhlouf, Matthew L Senjem, Melissa E Murray and 10 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 3 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  12. Tablet-based Cognitive Assessment Tool (TabCAT) in a multisite study of early-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  13. Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  14. Can Frontal Assessment Battery Discriminate between Patients with Alzheimer's and Frontotemporal Dementia?Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. AβJournal of Alzheimer's disease : JAD · 2025
    Article
  19. Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Ryan A TownleyDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0002-3566-3969
Jonathan Graff-RadfordDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0003-2770-0691
William G MantyhDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.
Hugo BothaDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0003-4390-685X
Angelina J PolsinelliDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55902, USA.
Scott A PrzybelskiDepartment of Biomedical Statistics, Mayo Clinic, Rochester, MN 55902, USA.
Mary M MachuldaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55902, USA.
Ahmed T MakhloufDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0001-8068-522X
Matthew L SenjemDepartment of Diagnostic Radiology, Mayo Clinic, Rochester, MN 55902, USA.
Melissa E MurrayDepartment of Molecular Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Ross R ReichardDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55902, USA.
Rodolfo SavicaDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.
Bradley F BoeveDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.
Daniel A DrubachDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.
Keith A JosephsDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.
David S KnopmanDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.
Val J LoweDepartment of Diagnostic Radiology, Mayo Clinic, Rochester, MN 55902, USA.
Clifford R JackDepartment of Diagnostic Radiology, Mayo Clinic, Rochester, MN 55902, USA.
Ronald C PetersenDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.
David T JonesDepartment of Neurology Mayo Clinic, Rochester, MN 55902, USA.
Mayo Clinic in Arizona · USMayo Clinic · USMayo Clinic in Florida · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BRUCE L MILLER · 2002 to 2026
$67.2M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 1999 to 2018
$36.9M
PREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
Understanding the role of TDP-43 in Alzheimers disease and FTLDR01AG037491 · NIA · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2024
$6.5M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Clinicopathologic and Neuroimaging Differences in Alzheimer's Disease VariantsR01AG054449 · NIA · MAYO CLINIC JACKSONVILLE · PI MURRAY, MELISSA ERIN · 2017 to 2021
$3.9M
Development, Validation, and Application of an Imaging based CVD ScaleR01NS097495 · NINDS · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 2016 to 2020
$2.9M
NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG037491NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG054449NIA NIH HHS R37 AG011378NIA NIH HHS T32 AG023481NIA NIH HHS U01 AG006786NINDS NIH HHS R01 NS097495
6 · The paper itself

Abstract

We report a group of patients presenting with a progressive dementia syndrome characterized by predominant dysfunction in core executive functions, relatively young age of onset and positive biomarkers for Alzheimer's pathophysiology. Atypical frontal, dysexecutive/behavioural variants and early-onset variants of Alzheimer's disease have been previously reported, but no diagnostic criteria exist for a progressive dysexecutive syndrome. In this retrospective review, we report on 55 participants diagnosed with a clinically defined progressive dysexecutive syndrome with

Indexed as

CSF biomarkersdysexecutiveearly-onset Alzheimer’s diseaseFDG-PETtau PET

Identifiers

PMID32671341
PMCPMC7325839
OpenAlexW3031694559

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.