Evidence map›Paper›PMID 32671290›Full record

ArticleBioactive materials2020

Novel fibrin-fibronectin matrix accelerates mice skin wound healing.

Carlos Poblete Jara, Ou Wang, Thais Paulino do Prado, Ayman Ismail, Frank Marco Fabian, Han Li, Licio A Velloso, Mark A Carlson, William Burgess, Yuguo Lei and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
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  7. Article
  8. Article
  9. Selective epithelial expression of KRASScientific reports · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Polymeric biomaterials for wound healing.Frontiers in bioengineering and biotechnology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Carlos Poblete JaraNursing School, University of Campinas, Campinas, SP, Brazil.
Ou WangDepartment of Chemical and Biomolecular Engineering, University of Nebraska, Lincoln, NE, USA.
Thais Paulino do PradoNursing School, University of Campinas, Campinas, SP, Brazil.
Ayman IsmailDepartment of Chemical and Biomolecular Engineering, University of Nebraska, Lincoln, NE, USA.
Frank Marco FabianDepartment of Chemical and Biomolecular Engineering, University of Nebraska, Lincoln, NE, USA.
Han LiDepartment of Chemical and Biomolecular Engineering, University of Nebraska, Lincoln, NE, USA.
Licio A VellosoLaboratory of Cell Signaling, University of Campinas, Campinas, SP, Brazil.
Mark A CarlsonDepartment of Surgery, University of Nebraska Medical Center and the VA Nebraska-Western Iowa Health Care System, USA.
William BurgessDepartment of Chemical and Biomolecular Engineering, University of Nebraska, Lincoln, NE, USA.
Yuguo LeiDepartment of Chemical and Biomolecular Engineering, University of Nebraska, Lincoln, NE, USA.
William H VelanderDepartment of Chemical and Biomolecular Engineering, University of Nebraska, Lincoln, NE, USA.
Eliana P AraújoNursing School, University of Campinas, Campinas, SP, Brazil.
University of Nebraska–Lincoln · USUniversidade Estadual de Campinas (UNICAMP) · BRVA Nebraska Western Iowa Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma fibrinogen (F1) and fibronectin (pFN) polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound healing. About 90% of plasma F1 has a homodimeric pair of γ chains (γγF1), and 10% has a heterodimeric pair of γ and more acidic γ' chains (γγ'F1). We have synthesized a novel fibrin matrix exclusively from a 1:1 (molar ratio) complex of γγ'F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII (rFXIIIa). In this matrix, the fibrin nanofibers were decorated with pFN nanoclusters (termed γγ'F1:pFN fibrin). In contrast, fibrin made from 1:1 mixture of γγF1 and pFN formed a sporadic distribution of "pFN droplets" (termed γγF1+pFN fibrin). The γγ'F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells (HUVECs) relative to the γγF1+FN fibrin. Three dimensional (3D) culturing showed that the γγ'F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human fibroblasts. HUVECs in the 3D γγ'F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in the γγF1+pFN fibrin. Relative to γγF1+pFN fibrin, mouse dermal wounds that were sealed by γγ'F1:pFN fibrin exhibited accelerated and enhanced healing. This study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing.

Indexed as

FibrinFibronectinNanoclustersWound healing

Identifiers

PMID32671290
PMCPMC7334397
OpenAlexW3038438644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.