ArticleIranian journal of biotechnology2019
Expression of a New Recombinant Collagenase Protein of
Article in Iranian journal of biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Histopathological investigation of wound healing activities of Lucilia sericata Larva and Achillea sintenisii extract combinations in diabetic rat wound model.Medical and veterinary entomology · 2026Article
- Insect cell expression system: advances in applications, engineering strategies, and bioprocess development.Journal of biological engineering · 2025Review
- Cloning, expression and molecular analysis of recombinant Netrin-A protein ofSAGE open medicine · 2024Article
- Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review.Microorganisms · 2023Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToday, the use of maggot therapy has become widespread due to the increase in chronic ulcers in the world. The recombinant production of secreted enzymes from these larvae is a novel non-invasive method for the treatment of chronic ulcers.
objectivesIn the present study we decided to produce the recombinant form of collagenase enzyme in MATERIALS AND
methodscloned the coding sequences (residues 494-1705) of
resultsThe recombinant protein was verified by Western blotting. Furthermore, the biological activity of purified protein was measured in the presence of its specific substrate and its inhibitor, which was 67 IU.mL
conclusionConsidering to the broad applications of collagenase in medical sciences, for the first time, we cloned the
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