Evidence map›Paper›PMID 32671116›Full record

ArticleJournal of immunology research2020

Circulating Neutrophils of Nonalcoholic Steatohepatitis Patients Show an Activated Phenotype and Suppress T Lymphocytes Activity.

Laura Antonucci, Cristiana Porcu, Eleonora Timperi, Silvano Junior Santini, Gino Iannucci, Clara Balsano

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Article
  3. Mechanistic insights into the liver-brain axis during chronic liver disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  4. Review
  5. Molecular mechanisms in MASLD/MASH-related HCC.Hepatology (Baltimore, Md.) · 2025
    Review
  6. Article
  7. HFD Exacerbates Hepatic Lipid Metabolism Disorders After Cholecystectomy by Regulating the Bile Acid and Neutrophil Recruitment.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Anti-CD47 antibody treatment attenuates liver inflammation and fibrosis in experimental non-alcoholic steatohepatitis models.Liver international : official journal of the International Association for the Study of the Liver · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Laura Antonucci *Francesco Balsano Foundation, Rome, Italy.ORCID https://orcid.org/0000-0001-8965-2432
Cristiana Porcu *Francesco Balsano Foundation, Rome, Italy.
Eleonora TimperiDipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy.
Silvano Junior SantiniDepartment of Life, Health and Environment Sciences, University of L'Aquila, L'Aquila, Italy.
Gino IannucciDipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy.
Clara BalsanoFrancesco Balsano Foundation, Rome, Italy.ORCID https://orcid.org/0000-0002-9615-7031
Sapienza University of Rome · ITUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils or PolyMorphonuclear Neutrophils (PMNs) are key effector cells of the innate immune system and thanks to their remarkable plasticity, establish a cross talk with T cells modulating their survival and effector functions. During Nonalcoholic Steatohepatitis (NASH), the advanced form of hepatic steatosis or NAFL, PMNs infiltrate liver tissue, becoming a histological feature of NASH. Our aim was to evaluate the frequency of PMNs in NAFL and NASH patients in order to understand how they modulate the activity of circulating CD4

Indexed as

Blood CirculationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCohort StudiesDisease ProgressionFemaleHumansImmune ToleranceLymphocyte ActivationMaleMiddle AgedNeutrophil ActivationNeutrophilsNon-alcoholic Fatty Liver DiseaseSeverity of Illness Index

Identifiers

PMID32671116
PMCPMC7346102
OpenAlexW3040602563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.