ArticleFrontiers in molecular biosciences2020
An Ancient Residue Metabolomics-Based Method to Distinguish Use of Closely Related Plant Species in Ancient Pipes.
Article in Frontiers in molecular biosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 19 citations in OpenAlex.
- An archaeo-metabolomics approach for identifying cedar tar in archaeological samples: differentiating plant products and production processes.Scientific reports · 2026Article
- Microbiome characterization of a pre-Hispanic man from Zimapán, Mexico: Insights into ancient gut microbial communities.PloS one · 2025Article
- Utilization of a natural language processing-based approach to determine the composition of artifact residues.BMC bioinformatics · 2024Article
- Metabolomics in archaeological science: A review of their advances and present requirements.Science advances · 2023Review
- Examination of human osteoarchaeological remains as a feasible source of polar and apolar metabolites to study past conditions.Scientific reports · 2023Article
- Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya.Scientific reports · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Residues from ancient artifacts can help identify which plant species were used for their psychoactive properties, providing important information regarding the deep-time co-evolutionary relationship between plants and humans. However, relying on the presence or absence of one or several biomarkers has limited the ability to confidently connect residues to particular plants. We describe a comprehensive metabolomics-based approach that can distinguish closely related species and provide greater confidence in species use determinations. An ~1430-year-old pipe from central Washington State not only contained nicotine, but also had strong evidence for the smoking of
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