Evidence map›Paper›PMID 32671082›Full record

SynthesisFrontiers in medicine2020

Systematic Review and Meta-Analysis of Sex-Specific COVID-19 Clinical Outcomes.

Thushara Galbadage, Brent M Peterson, Joseph Awada, Alison S Buck, Danny A Ramirez, Jason Wilson, Richard S Gunasekera

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 9 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 9 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
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  4. Recent Advance Analysis of Recovery in Hospitalized People with COVID-19: A Systematic Review.International journal of environmental research and public health · 2022
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  7. Clinical significance of prognostic nutrition index in hospitalized patients with COVID-19: Results from single-center experience with systematic review and meta-analysis.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2021
    Pooled it
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  10. Article
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  12. Observational
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  14. COVID-19 and stroke in women: impact on clinical, psychosocial and research aspects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thushara GalbadageDepartment of Kinesiology and Health Science, Biola University, La Mirada, CA, United States.
Brent M PetersonDepartment of Kinesiology and Health Science, Biola University, La Mirada, CA, United States.
Joseph AwadaDepartment of Chemistry, Physics, and Engineering, Biola University, La Mirada, CA, United States.
Alison S BuckDepartment of Chemistry, Physics, and Engineering, Biola University, La Mirada, CA, United States.
Danny A RamirezDepartment of Chemistry, Physics, and Engineering, Biola University, La Mirada, CA, United States.
Jason WilsonDepartment of Mathematics and Computer Science, Biola University, La Mirada, CA, United States.
Richard S GunasekeraDepartment of Chemistry, Physics, and Engineering, Biola University, La Mirada, CA, United States.
Biola University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To successfully mitigate the extraordinary devastation caused by the Coronavirus disease 2019 (COVID-19) pandemic, it is crucial to identify important risk factors for this disease. One such neglected health determinant is the sex of the patient. This is an essential clinical characteristic, as it can factor into a patient's clinical management and preventative measures. Some clinical studies have shown disparities in the proportion between males and females that have more severe clinical outcomes or, subsequently, die from this disease. However, this association has not been unequivocally established. Thus, the purpose of this investigation was to examine the association between male sex and COVID-19 severity. We systematically reviewed the literature, identified studies that matched predetermined selection criteria, and performed a meta-analysis to evaluate the proportion of males among four disease severity categories. Appropriate assessment strategies were implemented to assess and minimize potential biases. The results of this meta-analysis indicated that males constituted a significantly higher proportion of those who had adverse clinical outcomes and died from COVID-19. As the coronavirus spread from the East to the West, male sex remained a consistent risk factor. Our results support the establishment of the male sex as an important risk factor for this disease. Early identification and appropriate medical care for males with lab-confirmed COVID-19 may substantially change the course of clinical prognosis, resulting in greater numbers of lives saved.

Indexed as

clinical outcomescoronavirusCOVID-19disparitymalemortalitypandemicSARS-CoV-2

Identifiers

PMID32671082
PMCPMC7331754
OpenAlexW3034393029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.