Evidence map›Paper›PMID 32671057›Full record

ArticleFrontiers in cell and developmental biology2020

Kensuke Kataoka, Ryota Kurimoto, Hiroki Tsutsumi, Tomoki Chiba, Tomomi Kato, Kana Shishido, Mariko Kato, Yoshiaki Ito, Yuichiro Cho, Osamu Hoshi and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Cyclic mechanical stimulation of TDCs improves tendon tissue maturationFrontiers in bioengineering and biotechnology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Advanced Gene Therapy Strategies for the Repair of ACL Injuries.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Kensuke KataokaDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Ryota KurimotoDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroki TsutsumiDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tomoki ChibaDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tomomi KatoDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Kana ShishidoDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Mariko KatoDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshiaki ItoDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Yuichiro ChoAnatomy and Physiological Science, Tokyo Medical and Dental University, Tokyo, Japan.
Osamu HoshiAnatomy and Physiological Science, Tokyo Medical and Dental University, Tokyo, Japan.
Ayako MimataResearch Core, Tokyo Medical and Dental University, Tokyo, Japan.
Yuriko SakamakiResearch Core, Tokyo Medical and Dental University, Tokyo, Japan.
Ryo NakamichiDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Martin K LotzDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Keiji NaruseDepartment of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Hiroshi AsaharaDepartment of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tokyo Medical and Dental University · JPScripps Research Institute · USJapan Agency for Medical Research and Development · JPOkayama University · JP

Funding

Transcriptional Regulation of ChondrogenesisR01AR050631 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ASAHARA, HIROSHI · 2004 to 2021
$5.8M
Transcription factor Mohawk in tendon and ligament degeneration and regenerationR01AR065379 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ASAHARA, HIROSHI · 2014 to 2018
$2.1M
The role of microRNAs in chondrogenesis and arthritisR56AR050631 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ASAHARA, HIROSHI · 2009 to 2009
$475k
NIAMS NIH HHS R01 AR050631NIAMS NIH HHS R01 AR065379NIAMS NIH HHS R56 AR050631
6 · The paper itself

Abstract

Tendons and ligaments are pivotal connective tissues that tightly connect muscle and bone. In this study, we developed a novel approach to generate tendon/ligament-like tissues with a hierarchical structure, by introducing the tendon/ligament-specific transcription factor Mohawk (MKX) into the mesenchymal stem cell (MSC) line C3H10T1/2 cells, and by applying an improved three-dimensional (3D) cyclic mechanical stretch culture system. In our developed protocol, a combination of stable

Indexed as

ligamentmechanical-stressMohawktendontissue engineering

Identifiers

PMID32671057
PMCPMC7326056
OpenAlexW3030924457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.