Evidence map›Paper›PMID 32671037›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Extracellular Matrix Mimicking Nanofibrous Scaffolds Modified With Mesenchymal Stem Cell-Derived Extracellular Vesicles for Improved Vascularization.

Dake Hao, Hila Shimshi Swindell, Lalithasri Ramasubramanian, Ruiwu Liu, Kit S Lam, Diana L Farmer, Aijun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dake HaoDepartment of Surgery, School of Medicine, University of California, Davis, Sacramento, CA, United States.
Hila Shimshi SwindellDepartment of Surgery, School of Medicine, University of California, Davis, Sacramento, CA, United States.
Lalithasri RamasubramanianDepartment of Surgery, School of Medicine, University of California, Davis, Sacramento, CA, United States.
Ruiwu LiuDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, United States.
Kit S LamDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, United States.
Diana L FarmerDepartment of Surgery, School of Medicine, University of California, Davis, Sacramento, CA, United States.
Aijun WangDepartment of Surgery, School of Medicine, University of California, Davis, Sacramento, CA, United States.
University of California, Davis · USShriners Hospitals for Children - Erie · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
Fetal Tissue Engineering to Treat Spina Bifida Before BirthR01NS100761 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WANG, AIJUN · 2017 to 2021
$1.7M
Guinea pigs as a model of in utero stem cell therapy for spina bifidaR03HD091601 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WANG, AIJUN · 2017 to 2018
$157k
NCI NIH HHS P30 CA093373NICHD NIH HHS R03 HD091601NINDS NIH HHS R01 NS100761
6 · The paper itself

Abstract

The network structure and biological components of natural extracellular matrix (ECM) are indispensable for promoting tissue regeneration. Electrospun nanofibrous scaffolds have been widely used in regenerative medicine to provide structural support for cell growth and tissue regeneration due to their natural ECM mimicking architecture, however, they lack biological functions. Extracellular vesicles (EVs) are potent vehicles of intercellular communication due to their ability to transfer RNAs, proteins, and lipids, thereby mediating significant biological functions in different biological systems. Matrix-bound nanovesicles (MBVs) are identified as an integral and functional component of ECM bioscaffolds mediating significant regenerative functions. Therefore, to engineer EVs modified electrospun scaffolds, mimicking the structure of the natural EV-ECM complex and the physiological interactions between the ECM and EVs, will be attractive and promising in tissue regeneration. Previously, using one-bead one-compound (OBOC) combinatorial technology, we identified LLP2A, an integrin α4β1 ligand, which had a strong binding to human placenta-derived mesenchymal stem cells (PMSCs). In this study, we isolated PMSCs derived EVs (PMSC-EVs) and demonstrated they expressed integrin α4β1 and could improve endothelial cell (EC) migration and vascular sprouting in an

Indexed as

electrospun nanofibrous scaffoldextracellular vesicleintegrin-based ligandmesenchymal stem celltissue regenerationvascularization

Identifiers

PMID32671037
PMCPMC7329993
OpenAlexW3037251561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.