ArticleFrontiers in bioengineering and biotechnology2020
Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization.
Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 137 citations in OpenAlex.
- Bioactive PLA Filament with Antibacterial and Ion-Releasing Properties for Additive Manufacturing of Bone Scaffolds: QbD-Guided Development.Pharmaceutics · 2026Article
- Evaluation of the Biological Response to Coating 3D-Printed PLA Scaffolds with Coaxial Gelatin-Based Electrospun Fibers.Biomimetics (Basel, Switzerland) · 2026Article
- Synergistic Effects of Bioactive Glass on the Physicochemical Properties and In Vitro Bioactivity of 3D-Printed PCL Scaffolds.Materials (Basel, Switzerland) · 2026Article
- Comparative mechanical characterisation of 13-93 bioactive glass and hybrid scaffolds for bone regeneration.Scientific reports · 2026Article
- Review
- Biocomposite-Based Biomimetic Plate for Alternative Fixation of Proximal Humerus Fractures.Biomimetics (Basel, Switzerland) · 2025Article
- Rheological, Structural, and Biological Trade-Offs in Bioink Design for 3D Bioprinting.Gels (Basel, Switzerland) · 2025Review
- New Frontiers in 3D Printing Using Biocompatible Polymers.International journal of molecular sciences · 2025Review
- Advanced progress of adipose-derived stem cells-related biomaterials in maxillofacial regeneration.Stem cell research & therapy · 2025Review
- 3D-Printed Triply Periodic Minimal Surface Ceramic Scaffold Loaded With Bone Morphogenetic Protein-2 and Zoledronic for Cranium Defect Repairment.Journal of tissue engineering and regenerative medicine · 2025Article
- Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications.Advanced healthcare materials · 2024Review
- 3D-Printed Poly(ester urethane)/Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/Bioglass Scaffolds for Tissue Engineering Applications.Polymers · 2024Article
- Effect of the Addition of Inorganic Fillers on the Properties of Degradable Polymeric Blends for Bone Tissue Engineering.Molecules (Basel, Switzerland) · 2024Article
- Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds.Journal of materials chemistry. B · 2024Review
- 3D-printed PCL framework assembling ECM-inspired multi-layer mineralized GO-Col-HAp microscaffold for in situ mandibular bone regeneration.Journal of translational medicine · 2024Article
- β-ecdysone/PLGA composite scaffolds promote skull defect healing in diabetic rat.Frontiers in bioengineering and biotechnology · 2024Article
- Biodegradable Polymers in Biomedical Applications: A Review-Developments, Perspectives and Future Challenges.International journal of molecular sciences · 2023Review
- Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area.Nanomaterials (Basel, Switzerland) · 2023Review
- 3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering.Materials today. Bio · 2023Article
- Bioceramic scaffolds with triply periodic minimal surface architectures guide early-stage bone regeneration.Bioactive materials · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Critical size bone defects are regularly treated by auto- and allograft transplantation. However, such treatments require to harvest bone from patient donor sites, with often limited tissue availability or risk of donor site morbidity. Not requiring bone donation, three-dimensionally (3D) printed implants and biomaterial-based tissue engineering (TE) strategies promise to be the next generation therapies for bone regeneration. We present here polylactic acid (PLA)-bioactive glass (BG) composite scaffolds manufactured by fused deposition modeling (FDM), involving the fabrication of PLA-BG composite filaments which are used to 3D print controlled open-porous and osteoinductive scaffolds. We demonstrated the printability of PLA-BG filaments as well as the bioactivity and cytocompatibility of PLA-BG scaffolds using pre-osteoblast MC3T3E1 cells. Gene expression analyses indicated the beneficial impact of BG inclusions in FDM scaffolds regarding osteoinduction, as BG inclusions lead to increased osteogenic differentiation of human adipose-derived stem cells in comparison to pristine PLA. Our findings confirm that FDM is a convenient additive manufacturing technology to develop PLA-BG composite scaffolds suitable for bone tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.