Evidence map›Paper›PMID 32670900›Full record

ReviewJournal of International Society of Preventive & Community Dentistry

How Fluoride Protects Dental Enamel from Demineralization.

James Patrick Simmer, Nina C Hardy, Afriti F Chinoy, John D Bartlett, Jan C-C Hu

Open access · greenAbstract readReview
In one paragraph

Review in Journal of International Society of Preventive & Community Dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Effect of Fluoride Varnish on Enamel Microhardness: An in vitro Study.Clinical, cosmetic and investigational dentistry · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Strictinin: A Key Ingredient of Tea.Molecules (Basel, Switzerland) · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

James Patrick SimmerDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Nina C HardyDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Afriti F ChinoyDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
John D BartlettDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.
Jan C-C HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
University of Michigan–Ann Arbor · USThe Ohio State University · US

Funding

Proteomics and Genetics of Enamel and DentinR01DE015846 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HU, JAN CHING CHUN · 2004 to 2019
$5.7M
DSPP Function, Pathophysiology, and Genetic DiagnosisR01DE027675 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIMMER, JAMES P · 2018 to 2022
$2.4M
NIDCR NIH HHS R01 DE015846NIDCR NIH HHS R01 DE027675
6 · The paper itself

Abstract

introductionHow fluoride (F MATERIALS AND

methodsWe approximate that dental enamel is composed of calcium hydroxyapatite (HAP), a sparingly soluble ionic solid with the chemical formula Ca

resultsThe electrostatic forces binding ionic solids together are described by Coulomb's law, which shows that attractions between opposite charges increase greatly as their separation decreases. Relatively large phosphate ions (PO

conclusionBecause of its more compact crystal structure, the Ksp for fluorapatite (FAP) is lower than the Ksp for HAP, so its ion product, [Ca

Indexed as

Carieshydroxyapatitesolubility product constanttooth

Identifiers

PMID32670900
PMCPMC7339990
OpenAlexW3014614162

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.