ArticlePerspectives in clinical research
Recruitment and retention of the participants in clinical trials: Challenges and solutions.
Article in Perspectives in clinical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Blockchain Smart Contracts for Automating Clinical Trials: Systematic Review and Proposed System Architecture.JMIR medical informatics · 2026Pooled it
- The usage of population and disease registries as pre-screening tools for clinical trials, a systematic review.Systematic reviews · 2024Pooled it
- Barriers and facilitators for recruiting and retaining male participants into longitudinal health research: a systematic review.BMC medical research methodology · 2024Pooled it
- Repurposing effect of cardiovascular-metabolic drug to increase lifespan: a systematic review of animal studies and current clinical trial progress.Frontiers in pharmacology · 2024Pooled it
- Trial
- Feasibility and Tolerability of Daily Theta Burst Stimulation in Autistic Youth with Intellectual Disabilities and Minimally Speaking Status: A Pilot Double-Blind Randomized Sham-Controlled Trial.Journal of autism and developmental disorders · 2025Trial
- The Feasibility of the Diabetes Self-Management Coaching Program in Primary Care: A Mixed-Methods Randomized Controlled Feasibility Trial.International journal of environmental research and public health · 2024Trial
- Email-Based Recruitment Into the Health eHeart Study: Cohort Analysis of Invited Eligible Patients.Journal of medical Internet research · 2023Trial
- Trial
- Trial
- Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic.British journal of cancer · 2023Trial
- Dropout risk and effectiveness of retention strategies in the Memory Advancement by Intranasal Insulin in Type 2 Diabetes (MemAID) Clinical Trial.Contemporary clinical trials · 2023Trial
- Evaluation of electronic recruitment efforts of primary care providers as research subjects during the COVID-19 pandemic.BMC primary care · 2022Trial
- Beyond prediction: an evidenced-based framework for assessing site selection decisions.Therapeutic innovation & regulatory science · 2026Article
- Moving toward precision communication in pediatric oncology clinical trials: An outline of a conceptual framework to support caregiver decision-making.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Recruitment of healthy third-trimester pregnant women and their newborns into a prospective dental study at a primary health care clinic.BMC pregnancy and childbirth · 2026Article
- Article
- Attrition in Cochlear Implant Research: Sociodemographic, Audiologic, and Performance Variables.The Laryngoscope · 2026Article
- Unique Digital Images as Incentives in Clinical Trials: A Digital Shift Toward Meaningful Participation.Journal of medical Internet research · 2026Article
- Remote alcohol administration: A qualitative study of barriers and facilitators to potential participation.Experimental and clinical psychopharmacology · 2026Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug development is a tedious and expensive procedure and it takes roughly 10 to 15 years to take a potential treatment from bench to bedside and costs the pharmaceutical companies as much as USD ~2 billion for the process. Delay in investigator-initiated studies can cause financial loss to grant providers (either public or private) and investigator's reputation may also be at stake. Participant recruitment and retention are two major bottlenecks in conducting clinical trials and contribute vastly to the delays. They are essential for both scientific validity of the clinical study and economic reasons. Thus, issues in recruitment and retention should be addressed and minimized. A proper recruitment and retention plan incorporating adequate communication between all stakeholders will eventually avoid the delays in drug development and make treatments available to the consumer at an earlier date and at a more affordable price. Awareness of challenges and reviewing strategies that can optimise recruitment and retention will facilitate drug development. The article gives a first-person perspective on challenges and proposed solutions from an experienced clinical study centre in a tertiary care hospital.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.