ArticlePerspectives in clinical research
Clinical trials during the COVID-19 pandemic: Challenges of putting scientific and ethical principles into practice.
Article in Perspectives in clinical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Research ethics and integrity challenges in accelerated clinical trials, an interview study.BMC medical ethics · 2025Article
- Principal investigators' experience of COVID-19 therapeutic clinical trials in Japan: a qualitative study.BMJ open · 2025Article
- Article
- Key ethical issues encountered during COVID-19 research: a thematic analysis of perspectives from South African research ethics committees.BMC medical ethics · 2023Article
- A Survey on Methodological Issues of Clinical Research Studies Reviewed by Independent Ethic Committees during the COVID-19 Pandemic in Italy.International journal of environmental research and public health · 2022Article
- Health science research barriers and facilitators in the midst of the COVID-19 crisis: scoping reviewRevista colombiana de obstetricia y ginecologia · 2021Article
- Patient and Citizen Participation in the Identification of Ethical Considerations Aiming to Address Uncertainty in the Evaluation of Promising Interventions in a Pandemic Context.Frontiers in medical technology · 2021Article
- Prerequisite of doing clinical trial with drugs in COVID-19 patients: Situational experience.Perspectives in clinical researchArticle
- A narrative review of the challenges, ethical frameworks, and guidelines in the setting of COVID-19 healthcare and research.Perspectives in clinical researchArticle
- Real-world data in COVID-19 pandemic: An essential unmet health-care need.Perspectives in clinical researchArticle
- Consent concerns in clinical trials of investigational therapies for COVID-19: Vulnerability versus voluntariness.Perspectives in clinical researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Global pandemic of COVID-19 is a serious unmet medical need requiring clinical research into effective therapies. Clinical trials during pandemics of infections face complex challenges of putting scientific and ethical principles into practice. Some of these issues - selection of investigational product and participants, study design, assessment of efficacy and safety, ethics review, informed consent and publication, sample size, and publications - require in-depth consideration in planning and implementation of clinical trials during pandemics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.