Evidence map›Paper›PMID 32670812›Full record

ArticleJournal of traditional and complementary medicine2020

A ketogenic diet exerts beneficial effects on body composition of cancer patients during radiotherapy: An interim analysis of the KETOCOMP study.

Rainer J Klement, Gabriele Schäfer, Reinhart A Sweeney

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02516501 (Investigating the Impact of a Ketogenic Diet Intervention During Radiotherapy on Body Composition), which is not on this map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02516501 nacompletednot on this map

Investigating the Impact of a Ketogenic Diet Intervention During Radiotherapy on Body Composition: A Pilot Trial

TypeinterventionalSponsorMVZ Leopoldina GmbHRan2015 to 2021Enrolled156ConditionsNeoplasmsArmsMyAmino, betaquik, Radio(chemo)therapy
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  14. The Ketogenic Diet in Colorectal Cancer: A Means to an End.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rainer J KlementDepartment of Radiation Oncology, Leopoldina Hospital, Schweinfurt, Germany.
Gabriele SchäferDepartment of Radiation Oncology, Leopoldina Hospital, Schweinfurt, Germany.
Reinhart A SweeneyDepartment of Radiation Oncology, Leopoldina Hospital, Schweinfurt, Germany.
Leopoldina Krankenhaus Schweinfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimKetogenic diets (KDs) have gained interest as a complementary treatment for cancer patients. Here we present first results of our ongoing KETOCOMP study (NCT02516501) concerning body composition changes among rectal, breast and head & neck cancer (HNC) patients who consumed a KD during curative radiotherapy (RT). EXPERIMENTAL PROCEDURE: Sixty-one patients eating a non-ketogenic diet were compared to 20 patients on a KD supplemented with 10 g essential amino acids on RT days. Body composition was measured prior to and weekly during RT using 8-electrode bioimpedance analysis. Longitudinal body composition data were analyzed using linear mixed effects models. RESULTS AND

conclusionPatients on the KD exhibited nutritional ketosis, defined as serum β-hydroxybutyrate levels ≥0.5 mmol/l, in a median of 69.0% of blood measurements (range 0-100%) performed in our clinic. In rectal and breast cancer patients, KD was significantly associated with a loss of 0.5 and 0.4 kg fat mass per week (p = 0.00089 and 8.49 × 10

Indexed as

BHB, β-hydroxybutyrateBIA, Bioimpedance analysisBioimpedance analysisBreast cancerBW, Body weightFFM, Fat-free massFM, Fat massHead and neck cancerKD, Ketogenic dietKetogenic dietRectal cancerSMM, Skeletal muscle mass

Identifiers

PMID32670812
PMCPMC7340871
OpenAlexW2923962104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.