Evidence map›Paper›PMID 32670509›Full record

ArticleComputational and structural biotechnology journal2020

ProtExA: A tool for post-processing proteomics data providing differential expression metrics, co-expression networks and functional analytics.

George Minadakis, Kleitos Sokratous, George M Spyrou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George MinadakisDepartment of Bioinformatics, The Cyprus Institute of Neurology & Genetics, 6 International Airport Avenue, 2370 Nicosia, P.O. Box 23462, 1683 Nicosia, Cyprus.
Kleitos SokratousDepartment of Bioinformatics, The Cyprus Institute of Neurology & Genetics, 6 International Airport Avenue, 2370 Nicosia, P.O. Box 23462, 1683 Nicosia, Cyprus.
George M SpyrouDepartment of Bioinformatics, The Cyprus Institute of Neurology & Genetics, 6 International Airport Avenue, 2370 Nicosia, P.O. Box 23462, 1683 Nicosia, Cyprus.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ProTExA is a web-tool that provides a post-processing workflow for the analysis of protein and gene expression datasets. Using network-based bioinformatics approaches, ProTExA facilitates differential expression analysis and co-expression network analysis as well as pathway and post-pathway analysis. Specifically, for a given set of protein-gene expression data across samples, ProTExA: (1) performs statistical analysis and filtering to highlight the differentially expressed proteins-genes, (2) performs enrichment analysis to identify top-scored pathways, (3) generates pathway-to-pathway and pathway-to-gene networks (4) generates protein and gene co-expression networks using a variety of methodologies, and (5) applies clustering methodologies to identify sub-networks of co-expressed proteins-genes. The proposed web-tool is a simple yet informative tool, towards understanding and exploitation of protein and gene expression datasets, especially for those that do not have the expertise and local resources to replicate specific analyses in the context of collaborative and scientific data exchanging.

Indexed as

Differential gene expression analysisDifferential protein expression analysisGene co-expression networksProtein co-expression networksProteomics data post-processingTranscriptomic data post-processing

Identifiers

PMID32670509
PMCPMC7340977

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.