ArticleNature physics2020
The energy cost and optimal design for synchronization of coupled molecular oscillators.
Article in Nature physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A fundamental trade-off among noise suppression, response sensitivity and speed in biological feedback networks.NPJ systems biology and applications · 2026Article
- An order parameter for synchronisation of angular velocities.The European physical journal. Special topics · 2026Article
- Physical Frameworks and Theories on How Autonomous Biological Oscillators Synchronize.Advances in experimental medicine and biology · 2026Review
- ChemotaxingArXiv · 2025Article
- ChemotaxingbioRxiv : the preprint server for biology · 2025Article
- Topological phase locking in stochastic oscillators.Nature communications · 2025Article
- Stochastic thermodynamics for biological functions.Quantitative biology (Beijing, China) · 2025Review
- Energy partitioning in the cell cortex.Nature physics · 2024Article
- The efficiency of synchronization dynamics and the role of network syncreactivity.Nature communications · 2024Article
- A topological mechanism for robust and efficient global oscillations in biological networks.Nature communications · 2024Article
- Computation Implemented by the Interaction of Chemical Reaction, Clustering, and De-Clustering of Molecules.Biomimetics (Basel, Switzerland) · 2024Article
- Temperature compensation through kinetic regulation in biochemical oscillators.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A nonequilibrium allosteric model for receptor-kinase complexes: The role of energy dissipation in chemotaxis signaling.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex.Nature communications · 2023Article
- A minimal model of peripheral clocks reveals differential circadian re-entrainment in aging.Chaos (Woodbury, N.Y.) · 2023Article
- Physical Constraints in Intracellular Signaling: The Cost of Sending a Bit.Physical review letters · 2023Article
- Free energy dissipation enhances spatial accuracy and robustness of self-positioned Turing pattern in small biochemical systems.Journal of the Royal Society, Interface · 2023Article
- Energy Cost for Flocking of Active Spins: The Cusped Dissipation Maximum at the Flocking Transition.Physical review letters · 2022Article
- Eukaryotic gene regulation at equilibrium, or non?Current opinion in systems biology · 2022Article
- Role of the reaction-structure coupling in temperature compensation of the KaiABC circadian rhythm.PLoS computational biology · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
A model of coupled molecular biochemical oscillators is proposed to study nonequilibrium thermodynamics of synchronization. We find that synchronization of nonequilibrium oscillators costs addition energy to drive the exchange reaction (chemical interaction) between individual oscillators. By solving the steady state of the many-body system analytically, we show that the system goes through a nonequilibrium phase transition driven by energy dissipation, and the critical energy dissipation depends on both the frequency and strength of the exchange reaction. Moreover, our study reveals the optimal design for achieving maximum synchronization with a fixed energy budget. We apply our general theory to the Kai system in Cyanobacteria circadian clock and predict a relationship between the KaiC ATPase activity and synchronization of the KaiC hexamers. The theoretical framework can be extended to study thermodynamics of collective behaviors in other extended nonequilibrium active systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.