Evidence map›Paper›PMID 32670360›Full record

ArticleJournal of geriatric cardiology : JGC2020

Clinical value of detecting autoantibodies against β

Dong-Yan Hou, Lin Xu, Zhi-Yong Zhang, Xiao-Rong Xu, Xin Wang, Juan Zhang, Jia-Mei Liu, Hua Wang, Jin Chen, Lin Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric cardiology : JGC, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Dong-Yan HouHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Lin XuHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Zhi-Yong ZhangHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Xiao-Rong XuHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Xin WangHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Juan ZhangHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Jia-Mei LiuHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Hua WangHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Jin ChenHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Lin ZhangHeart Center, Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Beijing, China.
Beijing Chao-Yang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the possible association of anti-β

methodsA total of 267 HF patients were prospectively enrolled. Blood samples were measured by an enzyme-linked immunosorbent assay. All of the patients received carvedilol for their HF. Each patient was followed up for six months and their cardiac function was measured.

resultsThe final analysis encompassed 137 patients comprising 65 patients with three autoantibodies (positive group) and 72 patients without all three autoantibodies but with one or two autoantibodies (negative group). The frequency and geometric mean titer of anti-β

conclusionsCarvedilol treatment significantly decreases frequency and geometric mean titer in patients with all three autoantibodies, even up to complete ablation, and significantly improved cardiac function and remodelling. The effect of carvedilol is probably correlated to the presence of all three autoantibodies.

Indexed as

Adrenergic receptorsAutoantibodiesCardiac functionCarvedilolHeart failure

Identifiers

PMID32670360
PMCPMC7338933
OpenAlexW3043163680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.