Evidence map›Paper›PMID 32670261›Full record

ArticleFrontiers in immunology2020

Distribution of

Vincent Pernin, Anais Beyze, Ilan Szwarc, Nicole Bec, Céline Salsac, Esther Perez-Garcia, Georges Mourad, Pierre Merville, Jonathan Visentin, Helene Perrochia and 3 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04026087 (Characterization of the Subclass of Donor-specific Antibody Determined in Mass Spectrometry as a Risk Factor of Antibody Mediated Rejection in Renal Transplantation), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04026087 completednot on this map

Characterization of the Subclass of Donor-specific Antibody Determined in Mass Spectrometry as a Risk Factor of Antibody Mediated Rejection in Renal Transplantation

TypeobservationalSponsorUniversity Hospital, MontpellierRan2019 to 2023Enrolled100ConditionsAntibody-mediated Rejection
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Tailoring HLA antibody monitoring post-transplantation.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Prospective assessment of pre-existing andFrontiers in immunology · 2023
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vincent PerninDepartment of Nephrology, Dialysis and Transplantation, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Anais BeyzeInstitute for Regenerative Medicine & Biotherapy (IRMB), University of Montpellier, INSERM, Montpellier, France.
Ilan SzwarcDepartment of Nephrology, Dialysis and Transplantation, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Nicole BecInstitute for Regenerative Medicine & Biotherapy (IRMB), University of Montpellier, INSERM, Montpellier, France.
Céline SalsacInstitute for Regenerative Medicine & Biotherapy (IRMB), University of Montpellier, INSERM, Montpellier, France.
Esther Perez-GarciaInstitute for Regenerative Medicine & Biotherapy (IRMB), University of Montpellier, INSERM, Montpellier, France.
Georges MouradDepartment of Nephrology, Dialysis and Transplantation, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Pierre MervilleDepartment of Nephrology, Transplantation, Dialysis and Apheresis, Pellegrin University Hospital, Bordeaux, France.
Jonathan VisentinImmuno ConcEpT, UMR CNRS 5164, Bordeaux, France.
Helene PerrochiaDepartment of Pathology, Montpellier University Hospital, Montpellier, France.
Christian LarroqueInstitute for Regenerative Medicine & Biotherapy (IRMB), University of Montpellier, INSERM, Montpellier, France.
Lionel CouziDepartment of Nephrology, Transplantation, Dialysis and Apheresis, Pellegrin University Hospital, Bordeaux, France.
Moglie Le QuintrecDepartment of Nephrology, Dialysis and Transplantation, Montpellier University Hospital, University of Montpellier, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Donor-specific antibodies (DSAs) are the main risk factor for antibody-mediated rejection (ABMR) and graft loss but could have variable pathogenicity according to their IgG subclass composition. Luminex-based test might lack sensitivity for the detection of IgG subclasses and this test does not allow quantifying the relative abundance of each IgG subclass. We investigated the precise repartition of each DSA subclass and their role in ABMR occurrence and severity, using an innovative mass spectrometry-based method. Between 2014 and 2018, we enrolled 69 patients who developed

Indexed as

Tandem Mass SpectrometryAdultAgedBiomarkersFemaleFranceGraft RejectionHumansImmunoglobulin GIsoantibodiesKidney TransplantationMaleMiddle AgedPredictive Value of TestsProspective StudiesRisk FactorsBiomarkersImmunoglobulin GIsoantibodiesantibody-mediated rejectionde novo DSAIgG subclasskidney transplantationmass spectrometry

Identifiers

PMID32670261
PMCPMC7326073

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.