ArticleFrontiers in microbiology2020
Methods for Establishment and Maintenance of Germ-Free Rat Models.
Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
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- Implications of neurogenesis in depression through BDNF: rodent models, regulatory pathways, gut microbiota, and potential therapy.Molecular psychiatry · 2025Review
- Small intestinal bacterial overgrowth as one of the diagnostic markers of hypertension.Scientific reports · 2025Article
- Optimized cesarean techniques, IVF use, and foster strain selection enhance germ-free mouse production efficiency.Scientific reports · 2025Article
- Gut virome: New key players in the pathogenesis of inflammatory bowel disease.World journal of methodology · 2025Review
- Oxidized Polyunsaturated Fatty Acid Promotes Colitis and Colitis-Associated Tumorigenesis in Mice.Journal of Crohn's & colitis · 2025Article
- Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice.Journal of advanced research · 2025Article
- What we need to know about the germ-free animal models.AIMS microbiology · 2024Review
- The gut microbiome and hypertension.Nature reviews. Nephrology · 2023Review
- Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies.Nature · 2023Review
- Sterility testing of germ-free mouse colonies.Frontiers in immunology · 2023Review
- Utility of Human Relevant Preclinical Animal Models in Navigating NAFLD to MAFLD Paradigm.International journal of molecular sciences · 2022Review
- Gut Microbiota Composition in Relation to the Metabolism of Oral Administrated Resveratrol.Nutrients · 2022Article
- The Role of Dihydroresveratrol in Enhancing the Synergistic Effect ofResearch (Washington, D.C.) · 2022Article
- Improved functionality of Ligilactobacillus salivarius Li01 in alleviating colonic inflammation by layer-by-layer microencapsulation.NPJ biofilms and microbiomes · 2021Article
- Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease.Frontiers in cellular and infection microbiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Numerous studies have demonstrated that the gut microbiota plays a vital role in human health and disease development. Although the number of studies on host-microbiota interactions have increased in recent years, the underlying pathogenesis of dysbiosis-related diseases are still largely unknown. Germ-free (GF) rodent models, with the animals housed in sterile isolators and completely free of microbiota, are useful tools to advance our understanding of host-microbiota relationship
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.