ArticleFrontiers in microbiology2020
Silver Nanoparticles at Biocompatible Dosage Synergistically Increases Bacterial Susceptibility to Antibiotics.
Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 108 citations in OpenAlex.
- Effective bio-activities of the metal nanoparticles mycosynthesized by the plants' fungal endophytes.Microbial cell factories · 2026Review
- Are Silver and Gold Nanoparticles Obtained by 'Green' Synthesis Biocompatible?Nanomaterials (Basel, Switzerland) · 2026Review
- NIR-Activated Polydopamine Nanoparticles for Enterococcus faecalis Biofilm Eradication in Root Canal Disinfection.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Molecular identification, characterization and antibacterial activity of fungal-mediated silver nanoparticles against Bacillus subtilis sh3 and Klebsiella pneumoniae sh4.Scientific reports · 2026Article
- Critical Assessment of Intrinsic Antibacterial Properties and Photothermal Therapy Potential of MXene Nanosheets.ACS applied nano materials · 2026Article
- Novel biogenic silver nanoparticles produced byNanoscale advances · 2026Article
- 18β-Glycyrrhetinic acid-loaded silver nanoparticles mitigate neuroinflammation and endoplasmic reticulum stress in the brain tissue of diabetic rats.Iranian journal of basic medical sciences · 2026Article
- Progress in Nanofluid Technology: From Conventional to Green Nanofluids for Biomedical, Heat Transfer, and Machining Applications.Nanomaterials (Basel, Switzerland) · 2025Review
- Synergistic Interactions of Oxidized Amylose Silver Nanoparticles and Topically Applicable Antibiotics Against Staphylococcus aureus.Current microbiology · 2025Article
- Microanatomy related biocidal activity at cellular resolution and bone reconstruction potential of PEG EGaIn nanocapsules.NPJ biofilms and microbiomes · 2025Article
- Silver Nanoparticles (AgNPs) fromBiomolecules · 2025Article
- Metal-Based Approaches for the Fight against Antimicrobial Resistance: Mechanisms, Opportunities, and Challenges.Journal of the American Chemical Society · 2025Review
- Synergistic Activity ofInternational journal of molecular sciences · 2025Article
- Review
- Electrochemical Deposition of Silver Nanoparticle Assemblies on Carbon Ultramicroelectrode Arrays.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Advancing food safety with biogenic silver nanoparticles: Addressing antimicrobial resistance, sustainability, and commercial viability.Food chemistry: X · 2025Review
- Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria.Frontiers in cellular and infection microbiology · 2025Review
- Article
- Application of green silver nano-particles as anti-bacterial and photo-catalytic degradation of azo dye in wastewater.Scientific reports · 2024Article
- Bioinspired multifunctional silver nanoparticles by Smilax Chenensis and their enhanced biomedical and catalytic applications.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotics used to treat bacterial infections can become ineffective over time or result in the emergence of antibiotic resistant pathogens. With the advent of nanotechnology, silver nanoparticles (AgNPs) have gained significant attention as a therapeutic agent due to the well-known antimicrobial properties of silver. However, there are concerns and limited literature on the potential cytotoxicity of nanoparticles at effective antimicrobial concentrations. AgNPs prepared from silver nitrate with glucose reduction were characterized by surface plasmon resonance, dynamic light scattering, zeta potential analysis and transmission electron microscopy. The cytotoxicity of AgNPs towards human gingival fibroblasts over 7 days was determined using cell proliferation assays and confocal microscopy. AgNP MIC and antibacterial effects alone and in combination with 11 antibiotics were determined against a panel of nine microbial species including gram-positive and gram-negative bacterial species. AgNPs concentrations ≤ 1 μg/mL were non-cytotoxic but also showed no antibacterial effects. However, when combined with each of eleven antibiotics, the biocompatible concentration of AgNPs (1 μg/mL) resulted in significant inhibition of bacterial growth for multiple bacterial species that were resistant to either the antibiotics or AgNPs alone. This study presents a promising strategy with further testing
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.