ReviewFrontiers in psychiatry2020
Current Limitations for the Assessment of the Role of the Gut Microbiome for Attention Deficit Hyperactivity Disorder (ADHD).
Review in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Compositional and Functional Alterations in Intestinal Microbiota in Patients with Psychosis or Schizophrenia: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2023Pooled it
- Add-OnNutrients · 2024Trial
- Microbiota-driven mechanisms in multisystem diseases: integrative evidence across cardiovascular, metabolic, neurological and autoimmune disorders.Antonie van Leeuwenhoek · 2026Review
- Article
- Article
- Gut Microbiota Modulation of Dementia Related Complications.Aging and disease · 2025Review
- Fecal Microbiota Transplantation for Attention-Deficit/Hyperactivity Disorder: Mechanisms, Evidence, and Future Directions.International journal of general medicine · 2025Review
- Nutrition in the Management of ADHD: A Review of Recent Research.Current nutrition reports · 2023Review
- A bibliometric analysis of studies on gut microbiota in attention-deficit and hyperactivity disorder from 2012 to 2021.Frontiers in microbiology · 2023Article
- Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics.Frontiers in nutrition · 2023Review
- Long-Term Effects of an Oligoantigenic Diet in Children with Attention-Deficit/Hyperactivity Disorder (ADHD) on Core Symptomatology.Nutrients · 2022Article
- Sex-specific relationships of the infant microbiome and early-childhood behavioral outcomes.Pediatric research · 2022Article
- Gut microbiota and plasma cytokine levels in patients with attention-deficit/hyperactivity disorder.Translational psychiatry · 2022Article
- Effect ofJournal of personalized medicine · 2022Article
- Understanding the Role of the Gut Microbiome in Brain Development and Its Association With Neurodevelopmental Psychiatric Disorders.Frontiers in cell and developmental biology · 2022Review
- Article
- ADHD: Reviewing the Causes and Evaluating Solutions.Journal of personalized medicine · 2021Review
- Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications.Nutrients · 2021Review
- Biosynthesis and Characterization of Zinc Oxide Nanoparticles and Their Impact on the Composition of Gut Microbiota in Healthy and Attention-Deficit Hyperactivity Disorder Children.Frontiers in microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High throughput sequencing of bacterial 16S rRNA genes and metagenomes were applied to analyze complex microbial communities inhabiting the human gut and other body sites, and their role in numerous diseases. Studies in animals were important for elucidating the effects of the gut microbiota on the brain and behavior, and the responsible mechanisms. Recent studies in patients have identified bacterial taxa of the gut microbiome possibly impacting different neurological and psychiatric disorders including ADHD. Furthermore, antibiotic treatment of infections globally shape compositions of gut microbiota and might indirectly influence ADHD development. However, published studies revealed still partially incongruent results. Potential reasons for the still ill defined role of gut microbiota in ADHD comprise a) different study designs b) small number of patients c) different age groups analyzed d) inclusion of only treatment naive patients versus patients under medication e) differences of males versus females ratios and f) the heterogenous technology applied for microbiome sequence analysis. Furthermore, the complex interplay between the gut microbiome and individual host genetic factors requires much larger sample sizes and additional patient genome information. Alternative treatment options like probiotics or dietary interventions for ADHD therapy might offer new opportunities to prevent or treat this increasingly common disease. Clearly, further studies are needed to clarify molecular mechanisms imparting the gut brain axis as basis to modify commensal microbiota or their functions to target ADHD. The purpose of this review is to evaluate the most recent literature on the role of the gut microbiome in ADHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.