Evidence map›Paper›PMID 32670105›Full record

ArticleFrontiers in psychiatry2020

Is There an Association or Not?-Investigating the Association of Depressiveness, Physical Activity, Body Composition and Sleep With Mediators of Inflammation.

Frank M Schmidt, Roland Mergl, Juliane Minkwitz, Lesca M Holdt, Daniel Teupser, Ulrich Hegerl, Hubertus Himmerich, Christian Sander

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Obesity and Depression: Common Link and Possible Targets.CNS & neurological disorders drug targets · 2024
    Review
  2. Diet, Obesity, and Depression: A Systematic Review.Journal of personalized medicine · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Frank M SchmidtDepartment of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.
Roland MerglDepartment of Clinical Psychology and Psychotherapy, Bundeswehr University Munich, Munich, Germany.
Juliane MinkwitzIFB Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
Lesca M HoldtInstitute of Laboratory Medicine, University Hospital Ludwig-Maximilians-University Munich, Munich, Germany.
Daniel TeupserInstitute of Laboratory Medicine, University Hospital Ludwig-Maximilians-University Munich, Munich, Germany.
Ulrich HegerlDepartment of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.
Hubertus HimmerichIFB Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.
Christian SanderDepartment of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.
Leipzig University · DELudwig-Maximilians-Universität München · DEIFB Adiposity Diseases · DEKing's College London · GBUniversität der Bundeswehr München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytokines are mediators of inflammation that contribute to a low-grade inflammation in different disorders like major depression and obesity. It still remains unclear which psychological and medical factors interact with cytokine regulation. In the current investigation, the association between levels of pro-and anti-inflammatory cytokines and anthropometrics, mood state (depressiveness), physical activity and sleep were investigated in a sample of community-dwelled adults.

methodsForty-nine subjects met the inclusion criteria for analyses and were assessed at two time-points (baseline (T1) and follow-up (T2), average T1-T2-interval = 215 days). Serum cytokine measures included the pro-inflammatory cytokines interleukin (IL)-2, IL-12, IFN-γ and TNF-α, the anti-inflammatory cytokines IL-4, IL-5, IL-10 and IL-13 and the granulocyte-macrophage colony-stimulating factor (GM-CSF); anthropometrics were assessed

resultsCorrelation analyses showed low-to moderate significant relationships between the majority of cytokines and the BDI2 at T1, positive correlation with weight and BMI at T1 and T2, and negative correlations with the number of steps and METs at T2 and T2. Regression analyses for T1 revealed that the BDI2 score was the best positive predictor for the concentrations of all nine cytokines, followed by the number of steps and the nightsleep duration as negative predictors. At T2, the amount of steps was found to be negatively associated with IL-4, IL5, IL-10, GM-CSF, IFN-γ, and TNF-α, whereas the BMI could significantly predict IL-12 and IL-13. The BDI2-score was not significantly associated with any of the cytokines. No associations could be found between dynamics in cytokines from T1 and T2 and changes in any of the variables. DISCUSSION: The present results indicate an influence of physical activity, subjective well-being and body composition on inflammatory mediators. Since there was no standardized intervention targeting the independent variables between T1 and T2, no assumptions on causality can be drawn from the association results.

Indexed as

cytokinesdepressioninflammationobesityphysical activity

Identifiers

PMID32670105
PMCPMC7330708
OpenAlexW3037380663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.