ArticleFrontiers in psychiatry2020
The THINC-it Tool for Cognitive Assessment and Measurement in Major Depressive Disorder: Sensitivity to Change.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03053362 (An Open-Label Clinical Trial Evaluating Sensitivity to Change in Cognition Using the THINC-it Following Treatment With Vortioxetine in Major Depressive Disorder), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open-Label Clinical Trial Evaluating Sensitivity to Change in Cognition Using the THINC-it Following Treatment With Vortioxetine in Major Depressive Disorder
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis.Brain, behavior, and immunity · 2022Pooled it
- Sleep, Steps, and Screens: Between- and within-person effects of digital markers of daily life behaviors on smartphone-based assessments of cognitive functioning in depression.Neuroscience applied · 2026Article
- Layered vulnerabilities in young adults with major depressive disorder: personality, coping, and cognition.Frontiers in psychiatry · 2026Article
- Article
- The Association Between Cognitive Functioning and Depression Severity: A Multiwave Longitudinal Remote Assessment Study.Depression and anxiety · 2025Article
- The THINC-it tool: temporal sensitivity to change over time.BMC psychiatry · 2024Article
- Psychometric Properties of the Korean Version of THINC-integrated Tool (THINC-it-K): A Tool for Screening Assessment of Cognitive Function in Patients with Major Depressive Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Article
- Tablet-Based Cognitive and Eye Movement Measures as Accessible Tools for Schizophrenia Assessment: Multisite Usability Study.JMIR mental health · 2024Article
- The feasibility and effectiveness of remote cognitive training on cognitive function and work performance in workers.Frontiers in psychology · 2024Article
- The association between persistent cognitive difficulties and depression and functional outcomes in people with major depressive disorder.Psychological medicine · 2023Observational
- Autonomic dysregulation, cognition and fatigue in people with depression and in active and healthy controls: observational cohort study.BJPsych open · 2023Article
- Factors associated with objective and subjective cognitive impairment in Chinese patients with acute major depressive disorder.BMC psychiatry · 2023Article
- Article
- Validation of the THINC-It Tool for Assessment of Cognitive Impairment in Patients with Bipolar Depression.Neuropsychiatric disease and treatment · 2023Article
- An App-Based Digit Symbol Substitution Test for Assessment of Cognitive Deficits in Adults With Major Depressive Disorder: Evaluation Study.JMIR mental health · 2022Article
- Depression and Cognitive Impairment: Current Understanding of Its Neurobiology and Diagnosis.Neuropsychiatric disease and treatment · 2022Review
- The Relationship Between Cognitive Dysfunction Through THINC-Integrated Tool (THINC-it) and Psychosocial Function in Chinese Patients With Major Depressive Disorder.Frontiers in psychiatry · 2021Article
- Assessment of memory deficits in psychiatric disorders: A systematic literature review.Journal of neurosciences in rural practiceReview
- The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHerein, we sought to determine the sensitivity to change in cognitive function, as measured by the THINC-it tool, in a sample of adults with major depressive disorder (MDD) receiving standardized antidepressant therapy.
methodsAdults meeting the DSM-5 criteria for MDD with at least moderate depressive symptom severity [
resultsAfter 8 weeks of treatment, adults with MDD exhibited improvement in cognitive function relative to healthy controls (
conclusionThe THINC-it tool demonstrates sensitivity to change in adults with MDD and is highly correlated with improvements on pencil and paper versions of DSST and TMTB. CLINICAL
trial registrationClinicalTrials.gov, identifier NCT03053362.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.