Evidence map›Paper›PMID 32670017›Full record

ArticleFrontiers in molecular neuroscience2020

Selective Expression of Nicotinic Receptor Sub-unit mRNA in Early Human Fetal Forebrain.

Ayman Alzu'bi, William Middleham, Mohammed Shoaib, Gavin J Clowry

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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  8. ReducedFrontiers in cell and developmental biology · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ayman Alzu'biBiosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
William MiddlehamBiosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Mohammed ShoaibBiosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Gavin J ClowryBiosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Newcastle University · GBYarmouk University · JO

Funding

Medical Research Council MR/R006237/1Wellcome Trust
6 · The paper itself

Abstract

Increasing evidence from animal and human studies indicate that exposure to nicotine during development, separated from the effects of smoking tobacco, can contribute to dysregulation of brain development including behavioral deficits. An RNAseq study of human fetal cerebral cortex demonstrated that 9 out of 16 genes for human nicotinic acetylcholine (ACh) receptor subunits are selectively expressed between 7.5 and 12 post-conceptional weeks (PCW). The most highly expressed subunit genes were

Indexed as

cerebral cortexdevelopmentganglionic eminencesglutamatergic neuronsinhibitory interneuronsnicotinenicotinic receptors

Identifiers

PMID32670017
PMCPMC7326072
OpenAlexW3026733470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.