ArticleFrontiers in neuroscience2020
Functional Connectivity Abnormalities of Brain Regions With Structural Deficits in Primary Insomnia Patients.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Effects of acupuncture on the brain in primary insomnia: a coordinate-based meta-analysis of fMRI studies.Frontiers in neurology · 2023Pooled it
- Different light color temperatures in the morning on the effectiveness of rehabilitation training in patients with ischemic stroke: a prospective, single-center, randomized controlled clinical trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Resting-State Functional Connectivity Alterations in Insomnia Disorder: A Systematic Review of Studies Published from 2020 to July 2025.Nature and science of sleep · 2026Review
- The effects of sleep disturbances on patients receiving methadone treatment for opioid use disorder: cortical thickness evidence.Frontiers in psychiatry · 2026Article
- Altered dynamic functional connectivity of orbitofrontal cortex underlies olfactory and cognitive impairment in late-life depression.Psychoradiology · 2026Article
- Cortical activation and functional connectivity in patients with chronic insomnia based on working memory tasks: a multi-channel near-infrared spectroscopy study.BMC psychiatry · 2025Article
- Preliminary investigation of the interactive role of physiological arousal and insomnia complaints in gray matter volume alterations in chronic widespread pain.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Dynamic changes in fractional amplitude of low-frequency fluctuations in patients with chronic insomnia.Frontiers in neuroscience · 2022Article
- Improved Regional Homogeneity in Chronic Insomnia Disorder After Amygdala-Based Real-Time fMRI Neurofeedback Training.Frontiers in psychiatry · 2022Article
- Altered Intrinsic Regional Spontaneous Brain Activity in Patients With Severe Obesity and Meibomian Gland Dysfunction: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in human neuroscience · 2022Article
- Functional Connectivity Density in the Sensorimotor Area is Associated with Sleep Latency in Patients with Primary Insomnia.Neuropsychiatric disease and treatment · 2022Article
- [Small-world network of patients with primary insomnia: a resting-state functional magnetic resonance imaging study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- The Abnormal Functional Connectivity in the Locus Coeruleus-Norepinephrine System Associated With Anxiety Symptom in Chronic Insomnia Disorder.Frontiers in neuroscience · 2021Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present study examined the abnormal resting state functional connections (RSFCs) in structural deficit brain regions of primary insomnia (PI) patients.
methodsThirty-three PI patients and 38 well-matched healthy controls participated in our study. We used voxel-based morphometry and RSFC to study functional connectivity abnormalities of brain regions with structural deficits in PI patients.
resultsPI patients showed decreased gray matter (GM) volume in the left dorsolateral prefrontal cortex, left orbitofrontal cortex (OFC), bilateral middle frontal gyrus (MFC), right inferior frontal gyrus (IFG), and left inferior temporal gyrus. Gray matter volume in the right MFC negatively correlated with Self-Rating Scale of Sleep (SRSS) scores, and GM volume in the right IFG negatively correlated with SRSS and Insomnia Severity Index (ISI) scores. Therefore, the right MFC and right IFG were selected as regions of interest for RSFC analysis. PI patients had weakened RSFC between the right inferior parietal gyrus (IPC) and the right MFC compared to the healthy controls and between the left OFC and right IFG. The RSFC between the right MFC and right IPC negatively correlated with SRSS scores. The RSFC between the right IFG and left OFC negatively correlated with SRSS, ISI, SAS, and SDS scores.
conclusionsThe present study found structural changes in the right MFC and right IFG accompanied by RSFC changes. This finding may provide novel insights into the neural mechanisms of PI
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