Evidence map›Paper›PMID 32669845›Full record

ArticleNeuropsychiatric disease and treatment2020

Review of Clinical Outcome Assessments in Pediatric Attention-Deficit/Hyperactivity Disorder.

Jessica T Markowitz, Dorothee Oberdhan, Anna Ciesluk, Alissa Rams, Sharon B Wigal

Open access · goldAbstract read
In one paragraph

Article in Neuropsychiatric disease and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jessica T MarkowitzResearch Department, Modus Outcomes, Cambridge, MA 02142, USA.
Dorothee OberdhanHEOR and Outcomes Management, Otsuka America Pharmaceutical, Inc, Rockville, MD 20850, USA.ORCID 0000-0003-1034-9049
Anna CieslukResearch Department, Modus Outcomes, Cambridge, MA 02142, USA.ORCID 0000-0003-1835-992X
Alissa RamsResearch Department, Modus Outcomes, Cambridge, MA 02142, USA.ORCID 0000-0001-9615-4546
Sharon B WigalDepartment of Pediatrics, University of California School of Medicine, Irvine, CA 92697-4089, USA.
Otsuka (United States) · USUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVarious clinical outcome assessments (COAs) are used in clinical research to assess and monitor treatment efficacy in pediatric attention-deficit/hyperactivity disorder (ADHD) trials. It is unclear whether the concepts assessed are those that are important to patients and their caregivers. The concepts measured by commonly used COAs in this population have not been explicitly compared.

methodsWe conducted reviews of the qualitative literature to extract information on pediatric ADHD-related concepts reported by pediatric patients, parents, and teachers. Using these concepts, we developed a conceptual framework of pediatric ADHD using both the

resultsOf the 27 COAs found in the empirical literature, 4 COAs assessed only DSM symptoms. The most comprehensive coverage of our conceptual framework was seen in the Swanson, Nolan, and Pelham Rating Scale-DSM-IV (SNAP-IV). Eighteen COAs were used in at least 1 clinical trial: ADHD-Rating Scale-IV (ADHD

conclusionWe identified symptoms and behavioral impacts from qualitative studies in pediatric ADHD that are not included in DSM-based criteria. Most COAs used in pediatric ADHD clinical trials measure only those symptoms listed in the DSM. While these COAs can measure symptom severity, they may not assess the full range of symptoms and impacts important to patients and their caregivers. Future research is needed to measure all concepts important to patients and caregivers within ADHD clinical trials.

Indexed as

adolescentsassessment scalesattention-deficit/hyperactivity disorderchildrenclinical outcome assessmentefficacypediatrics

Identifiers

PMID32669845
PMCPMC7335865
OpenAlexW3039058943

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.