Evidence map›Paper›PMID 32669837›Full record

ArticlePatient preference and adherence2020

Why Do People Living with HIV Adhere to Antiretroviral Therapy and Not Comorbid Cardiovascular Disease Medications? A Qualitative Inquiry.

Charles Muiruri, Isabelle P Sico, Julie Schexnayder, Allison R Webel, Nwora Lance Okeke, Christopher T Longenecker, Juan Marcos Gonzalez, Kelley A Jones, Sarah E Gonzales, Hayden B Bosworth

Abstract read
In one paragraph

Article in Patient preference and adherence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Observational
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Charles MuiruriDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.
Isabelle P SicoDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-6131-9141
Julie SchexnayderFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Allison R WebelFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Nwora Lance OkekeDepartment of Medicine, Duke University Medical Center, NC, USA.
Christopher T LongeneckerDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Juan Marcos GonzalezDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-5386-0907
Kelley A JonesDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.
Sarah E GonzalesDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-7860-3341
Hayden B BosworthDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-6188-9825

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI GEORGIA Doris TOMARAS · 2005 to 2026
$50.5M
Assess and Adapt to the Impact of COVID-19 on CVD Self Management and Prevention Care in Adults Living with HIV (AAIM-High)U01HL142099 · NHLBI · UNIVERSITY OF WASHINGTON · PI BOSWORTH, HAYDEN B, LONGENECKER, CHRIS TODD · 2018 to 2021
$4.8M
A Clinic-Based Behavioral Intervention to Reduce Cardiovascular Disease Risk in Persons Living with HIVK23HL137611 · NHLBI · DUKE UNIVERSITY · PI OKEKE, NWORA LANCE · 2018 to 2022
$895k
HSRD VA IK6 HX003161NHLBI NIH HHS K23 HL137611NHLBI NIH HHS U01 HL142099NIAID NIH HHS P30 AI064518
6 · The paper itself

Abstract

backgroundAfter achieving viral suppression, it is critical for persons living with HIV (PLWH) to focus on prevention of non-AIDS comorbidities such as cardiovascular disease (CVD) in order to enhance their quality of life and longevity of life. Despite PLWH elevated risk of developing CVD compared to individuals without HIV, PLWH do not often meet evidence-based treatment goals for CVD prevention; the reasons for PLWH not meeting guideline recommendations are poorly understood. The objective of this study was to identify the factors associated with adherence to CVD medications for PLWH who have achieved viral suppression.

methodsQualitative data were obtained from formative research conducted to inform the adaptation of a nurse-led intervention trial to improve cardiovascular health at three large academic medical centers in the United States. Transcripts were analyzed using content analysis guided by principles drawn from grounded theory.

resultsFifty-one individuals who had achieved viral suppression (<200 copies/mL) participated: 37 in 6 focus groups and 14 in individual semi-structured interviews. Mean age was 57 years (SD: 7.8); most were African Americans (n=31) and majority were male (n=34). Three main themes were observed. First, participants reported discordance between their healthcare providers' recommendations and their own preferred strategies to reduce CVD risk. Second, participants intentionally modified frequency of CVD medication taking which appeared to be related to low CVD risk perception and perceived or experienced side effects with treatment. Finally, participants discussed the impact of long-term experience with HIV care on adherence to CVD medication and motivational factors that enhanced adherence to heart healthy behaviors.

conclusionFindings suggest that future research should focus on developing interventions to enhance patient-provider communication in order to elicit beliefs, concerns and preferences for CVD prevention strategies. Future research should seek to leverage and adapt established evidence-based practices in HIV care to support CVD medication adherence.

Indexed as

cardiovascular diseasemedication adherencepersons living with HIVqualitative researchviral suppression

Identifiers

PMID32669837
PMCPMC7337208

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.