ArticleIsrael journal of chemistry2020
Base-Assisted C-H Bond Cleavage in Cross-Coupling: Recent Insights into Mechanism, Speciation, and Cooperativity.
Article in Israel journal of chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed.
- Elucidating Ligand-Dependent Selectivities in Pd-Catalyzed C-H Activations.Angewandte Chemie (International ed. in English) · 2025Article
- Using Yield Profiles to Study Reaction Mechanism.ACS catalysis · 2025Article
- A 100,000-Fold Increase in C-H Bond Acidity Gives Palladium a Key Advantage in C(spJournal of the American Chemical Society · 2025Article
- Palladium-Catalyzed Decarbonylative C-H Difluoromethylation of Azoles.Organic letters · 2025Article
- Deuteration of Arenes via Pd-Catalyzed C-H Activation: A Lesson in Nondirected C-H Activation, Isotopic Labeling, and NMR Characterization.Journal of chemical education · 2024Article
- Applications of Transition Metal-CatalyzedChemical reviews · 2024Review
- Opening a Pandora's Flask on a Prototype Catalytic Direct Arylation Reaction of Pentafluorobenzene: The AgOrganometallics · 2023Article
- Protodemetalation of (Bipyridyl)Ni(II)-Aryl Complexes Shows Evidence for Five-, Six-, and Seven-Membered Cyclic Pathways.Journal of the American Chemical Society · 2023Article
- Catalytic enantioselective alkenylation-heteroarylation of olefins: stereoselective syntheses of 5-7 membered azacycles and oxacycles.Chemical science · 2023Article
- C-H Activation by Isolable Cationic Bis(phosphine) Cobalt(III) Metallacycles.Journal of the American Chemical Society · 2022Article
- Site-Selective C-H Arylation of Diverse Arenes Ortho to Small Alkyl Groups.Angewandte Chemie (International ed. in English) · 2022Article
- Pd-catalysed C-H functionalisation of free carboxylic acids.Chemical science · 2022Review
- Ligand switchable site selectivity in C-H alkenylation of thiophenes by turnover-limiting step control.Chemical communications (Cambridge, England) · 2021Article
- Catalyst-Controlled Regioselectivity in Pd-Catalyzed Aerobic Oxidative Arylation of Indoles.Organometallics · 2021Article
- Mechanism of the Arene-Limited Nondirected C-H Activation of Arenes with Palladium*.Angewandte Chemie (International ed. in English) · 2021Article
- Direct Arylation of Simple Arenes with Aryl Bromides by Synergistic Silver and Palladium Catalysis.ACS catalysis · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
This review analyzes recent mechanistic studies that have provided new insights into how the structure of a metal complex influences the rate and selectivity of base-assisted C-H cleavage. Partitioning a broader mechanistic continuum into classes delimited by the polarization between catalyst and substrate during C-H cleavage is postulated as a method to identify catalysts favoring electrophilic or nucleophilic reactivity patterns, which may be predictive based on structural features of the metal complex (i.e., oxidation state, d-electron count, charge). Multi-metallic cooperativity and polynuclear speciation also provide new avenues to affect energy barriers for C-H cleavage and site selectivity beyond the limitations of single metal catalysts. An improved understanding of mechanistic nuances and structure-activity relationships on this important bond activation step carries important implications for efficiency and controllable site selectivity in non-directed C-H functionalization.
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Registered trials
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