Evidence map›Paper›PMID 32669716›Full record

ArticleNature2020

Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis.

Alejo E Rodriguez-Fraticelli, Caleb Weinreb, Shou-Wen Wang, Rosa P Migueles, Maja Jankovic, Marc Usart, Allon M Klein, Sally Lowell, Fernando D Camargo

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 286 citations in OpenAlex.

  1. Article
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  11. Mechanometabolism instructs hematopoietic stem cell specification.The Journal of experimental medicine · 2026
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Cell lineage tracing: Methods, applications, and challenges.Quantitative biology (Beijing, China) · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Review

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alejo E Rodriguez-FraticelliDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4017-8714
Caleb WeinrebHarvard Medical School, Department of Systems Biology, Boston, MA, USA.
Shou-Wen WangHarvard Medical School, Department of Systems Biology, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4569-1194
Rosa P MiguelesInstitute for Stem Cell Research, MRC Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, UK.
Maja JankovicDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Marc UsartDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Allon M KleinHarvard Medical School, Department of Systems Biology, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8913-7879
Sally LowellInstitute for Stem Cell Research, MRC Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, UK.
Fernando D CamargoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. fernando.camargo@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-5630-5909
Boston Children's Hospital · USHarvard University · USMRC Centre for Regenerative Medicine · GB

Funding

Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DANIEL G TENEN · 2017 to 2026
$24.6M
Molecular regulation of native hematopoiesisR01HL128850 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CAMARGO, FERNANDO · 2016 to 2024
$4.9M
Novel Growth Factor Regulators of Early ErythropoieisisR01HL141402 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KLEIN, ALLON MOSHE, SOCOLOVSKY, MERAV · 2018 to 2021
$2.6M
Droplet microfluidic technology for single cell cancer genomicsR33CA212697 · NCI · HARVARD MEDICAL SCHOOL · PI KLEIN, ALLON MOSHE · 2017 to 2019
$1.3M
mechanisms of in situ functional stem cell heterogeneity in native and transplantation hematopoiesisK99HL146983 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI RODRIGUEZ FRATICELLI, ALEJO EZEQUIEL · 2019 to 2020
$336k
Howard Hughes Medical InstituteMedical Research Council MR/K017047/1NCI NIH HHS R33 CA212697NHLBI NIH HHS K99 HL146983NHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL128850NHLBI NIH HHS R01 HL141402NIH HHS HL128850-01A1NIH HHS P01HL13147NIH HHS R33CA212697-01Wellcome TrustWellcome Trust WT103789AIA
6 · The paper itself

Abstract

Bone marrow transplantation therapy relies on the life-long regenerative capacity of haematopoietic stem cells (HSCs)

Indexed as

Cell LineageHematopoiesisSingle-Cell AnalysisAnimalsBasic Helix-Loop-Helix ProteinsCell Self RenewalCRISPR-Cas SystemsFemaleHematopoietic Stem CellsMiceBasic Helix-Loop-Helix ProteinsTcf15 protein, mouse

Identifiers

PMID32669716
PMCPMC7579674
OpenAlexW3043399522

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.